Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a protein that in humans is encoded by the TRPM2 gene.

2024年12月25日 · TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2) is a Protein Coding gene. Diseases associated with TRPM2 include Neuroblastoma and Epilepsy. Among its related pathways are Innate Immune System and Ion channel transport.

2018年4月19日 · Transient receptor potential melastatin 2 (TRPM2) is a calcium (Ca 2+)-permeable non-selective cation channel belonging to the TRP ion channel family. Oxidative...

2018年9月24日 · Transient receptor potential melastatin 2 (TRPM2) is a calcium-permeable, non-selective cation channel that has an essential role in diverse physiological processes such as core body...

TRPM2 is involved in several physiological and pathological processes in the brain through the modulation of multiple signaling pathways. The aim of the present review is to provide a brief summary of the current insights of TRPM2 role in health and disease to focalize our attention on future potential neuroprotective strategies.

2023年7月27日 · TRPM2 is a versatile and essential signaling molecule that plays diverse roles in Ca 2+ homeostasis and oxidative stress signaling, with implications in various diseases. Research evidence has shown that TRPM2 is a promising therapeutic target.

TRPM2 is a Ca (2+)-permeable nonselective cation channel embedded in the plasma membrane and/or lysosomal compartments that is primarily activated in a synergistic fashion by intracellular ADP-ribose (ADPr) and Ca (2+).

TRPM2 is a chanzyme consisting of a channel fused with an enzymatic domain, activated by ADP-ribose, NAD+, Ca2+, and heat. It is expressed in astrocytes and microglia, playing a role in immune cell function and gliosis, and its knockout reduces …

2023年10月18日 · TRPM2 mediates ADP-ribose and reactive oxygen species signalling in neurons, immunocytes and kidney epithelial cells, whereas TRPM8 is a cold-sensing channel that regulates organismal thermal...

2023年6月19日 · Recent studies showed the involvement of TRPM2 in pathogenesis factors of ischemic stroke as follows: by reducing oxidative stress in cardiomyocytes, TRPM2 reduces inflammation and stimulates the remodeling of the atria; it models endothelial dysfunction by deregulating the influx of calcium ions, mediates the damaging effects of ROS on the ...