TRPA1 mediates inflammation by inhibiting macrophage activation and inducing macrophage apoptosis. TRPA1 is upregulated in atherosclerotic plaques and modulates the transition of macrophages to an anti-inflammatory phenotype, thereby reducing atherosclerosis (Wang et …

While there is broad evidence that direct TRPA1 stimulation in nociceptors mediates acute pain responses, recent findings have shifted the focus to the TRPA1 expressed in glial cells as the critical factor to sustain chronic pain.

2019年2月1日 · The transient receptor potential ankyrin 1 (TRPA1) ion channel is expressed in pain-sensing neurons and other tissues and has become a major target in the development of novel pharmaceuticals. A remarkable feature of the channel is its long list of activators, many of which we are exposed to in dail …

TRPA1 is a non‐selective cation channel expressed in mammalian peripheral pain receptors, with a major role in chemonociception. TRPA1 has also been implicated in noxious cold and mechanical pain sensation.

The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of channels, is primarily localized to a subpopulation of primary sensory neurons of the trigeminal, vagal, and dorsal root ganglia.

2015年4月8日 · The TRPA1 ion channel (also known as the wasabi receptor) is a detector of noxious chemical agents encountered in our environment or produced endogenously during tissue injury or drug...

2024年12月25日 · The ankyrin-like receptor family (TRPA1) is a member of the transient receptor potential (TRP) superfamily of ion channels. TRPA1 is classed as a thermoTRP: a TRP channel which is gated by temperature and functions as a temperature transducer.

2023年9月5日 · TRPA1 plays a key role in somatosensation by acting as a sensor of thermal and chemical stimuli. TRPA1 antagonists have great potential in the treatment of pain, inflammation, pruritus, asthma, and Alzheimer's disease. Systematic collation on TRPA1 agonists and antagonists developed in recent years.

The Transient Receptor Potential Ankyrin 1 channel (TRPA1), is a member of the large TRP family of ion channels, and functions as a Ca(2+) permeable non-selective cation channel in many different cell processes, ranging from sensory to homeostatic tasks.

TRPA1 is required for acute and chronic inflammation. TRPA1-expressing sensory neurons that innervate the skin, airways, and GI tract detect irritants and release neuropeptides, such as neurokinin A, substance P, and calcitonin gene-related peptide, that promote and modulate inflammatory responses.