TRPA1 mediates inflammation by inhibiting macrophage activation and inducing macrophage apoptosis. TRPA1 is upregulated in atherosclerotic plaques and modulates the transition of …

While there is broad evidence that direct TRPA1 stimulation in nociceptors mediates acute pain responses, recent findings have shifted the focus to the TRPA1 expressed in glial cells as the …

2019年2月1日 · The transient receptor potential ankyrin 1 (TRPA1) ion channel is expressed in pain-sensing neurons and other tissues and has become a major target in the development of …

TRPA1 is a non‐selective cation channel expressed in mammalian peripheral pain receptors, with a major role in chemonociception. TRPA1 has also been implicated in noxious cold and …

The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation channel permeable to Ca (2+), Na (+), and K (+). TRPA1 is a promiscuous chemical …

2023年9月5日 · TRPA1 plays a key role in somatosensation by acting as a sensor of thermal and chemical stimuli. TRPA1 antagonists have great potential in the treatment of pain, …

2024年12月25日 · The ankyrin-like receptor family (TRPA1) is a member of the transient receptor potential (TRP) superfamily of ion channels. TRPA1 is classed as a thermoTRP: a TRP …

TRPA1 channels are required for neuronal excitation, the release of inflammatory neuropeptides, and subsequent pain hypersensitivity. TRPA1 is also activated by the release of inflammatory …

2015年4月8日 · The TRPA1 ion channel (also known as the wasabi receptor) is a detector of noxious chemical agents encountered in our environment or produced endogenously during …

4 天之前 · Transient receptor potential ankyrin 1 (TRPA1) is a sensory channel expressed in vagal afferent nerves that detect noxious stimuli. Trpa1 knockout accelerates age-related cardiac …