
Inflammation—the role of TRPA1 channel - PMC
TRPA1 mediates inflammation by inhibiting macrophage activation and inducing macrophage apoptosis. TRPA1 is upregulated in atherosclerotic plaques and modulates the transition of …
TRPA1 as a therapeutic target for nociceptive pain - PMC
While there is broad evidence that direct TRPA1 stimulation in nociceptors mediates acute pain responses, recent findings have shifted the focus to the TRPA1 expressed in glial cells as the …
TRPA1: a molecular view - PubMed
2019年2月1日 · The transient receptor potential ankyrin 1 (TRPA1) ion channel is expressed in pain-sensing neurons and other tissues and has become a major target in the development of …
TRPA1 channels: molecular sentinels of cellular stress and tissue ...
TRPA1 is a non‐selective cation channel expressed in mammalian peripheral pain receptors, with a major role in chemonociception. TRPA1 has also been implicated in noxious cold and …
TRPA1 - PubMed
The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation channel permeable to Ca (2+), Na (+), and K (+). TRPA1 is a promiscuous chemical …
Transient receptor potential ankyrin 1 (TRPA1) modulators: Recent ...
2023年9月5日 · TRPA1 plays a key role in somatosensation by acting as a sensor of thermal and chemical stimuli. TRPA1 antagonists have great potential in the treatment of pain, …
TRPA1 Gene - GeneCards | TRPA1 Protein | TRPA1 Antibody
2024年12月25日 · The ankyrin-like receptor family (TRPA1) is a member of the transient receptor potential (TRP) superfamily of ion channels. TRPA1 is classed as a thermoTRP: a TRP …
TRPA1: A gatekeeper for inflammation - PubMed
TRPA1 channels are required for neuronal excitation, the release of inflammatory neuropeptides, and subsequent pain hypersensitivity. TRPA1 is also activated by the release of inflammatory …
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015年4月8日 · The TRPA1 ion channel (also known as the wasabi receptor) is a detector of noxious chemical agents encountered in our environment or produced endogenously during …
Long-term dietary allyl isothiocyanate, a TRPA1 agonist, …
4 天之前 · Transient receptor potential ankyrin 1 (TRPA1) is a sensory channel expressed in vagal afferent nerves that detect noxious stimuli. Trpa1 knockout accelerates age-related cardiac …
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