TRAF6 is a TRAF human protein. The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily.

Tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) is an adaptor protein that mediates a wide array of protein-protein interactions via its TRAF domain and a RING finger domain that possesses non-conventional E3 ubiquitin ligase activity.

There are seven members: TRAF1-TRAF7, among those members, tumor necrosis factor receptor-associated factor 6 (TRAF6) is upregulated in various tumors, which has been related to tumorigenesis and development.

TRAF6 consists of an N-terminal Really Interesting New Gene (RING) domain, multiple zinc fingers, and a C-terminal TRAF domain. TRAF6 is an important therapeutic target for various disorders and structural studies of this protein are crucial for …

2024年12月25日 · TRAF6 (TNF Receptor Associated Factor 6) is a Protein Coding gene. Diseases associated with TRAF6 include Ectodermal Dysplasia 10A, Hypohidrotic/Hair/Nail Type, Autosomal Dominant and Hypophosphatasia, Adult. Among its related pathways are Toll Like Receptor 3 (TLR3) Cascade and p75 NTR receptor-mediated signalling.

2025年1月5日 · Title: METTL14 Regulates the m6A Modification of TRAF6 to Suppress Mitochondrial Dysfunction and Ferroptosis in Dopaminergic Neurons via the cGAS-STING Pathway. ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota.

2002年7月25日 · Here we report crystal structures of TRAF6, alone and in complex with TRAF6-binding peptides from CD40 and TRANCE-R (also known as RANK), members of the TNFR superfamily, to gain insight into...

TRAF6 regulates the abundance of RIPK1 and inhibits the RIPK1/RIPK3/MLKL necroptosis signaling pathway and affects the progression of colorectal cancer. Molecular determinants of TRAF6 binding specificity suggest that native interaction partners are not optimized for affinity.

1996年10月3日 · Here we report the identification of a new TRAF family member, designated TRAF6. When overexpressed in human 293 cells, TRAF6 activates NF-κB. A dominant-negative mutant of TRAF6 inhibits NF-κB...

Studies have increasingly found that TRAF6 is closely related to central nervous system diseases, such as stroke, Traumatic brain injury, neurodegenerative diseases and neuropathic pain. Further research on the pathophysiological mechanism may be expected to become the new targets for the treatment of central nervous system diseases.

TRAF6 has a unique TRAF domain and RING finger domain that mediate intracellular signaling events. In the immune system, TRAF6-mediated signaling has been shown to be critical for the development, homeostasis, and activation of a variety of immune cells, including B cells, T cells, dendritic cells, and macrophages.

Tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) is an adapter protein that mediates a wide array of protein-protein interactions via its TRAF domain and a RING finger domain that possesses non-conventional E3 ubiquitin ligase activity.

2023年11月28日 · Tumor necrosis factor receptor-associated factor 6 (TRAF6) is an E3 ubiquitin ligase that is extensively involved in the autophagy process by interacting with diverse autophagy...

2020年11月26日 · Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6), an E3 ubiquitin ligase, is a signal transduction molecule shared by the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) family and the TNFR superfamily. TRAF6 has a unique TRAF domain and RING finger domain that mediate intracellular signaling events.

TRAF6 is a ubiquitin E3 ligase that regulates the ubiquitination of the IKK complex and the activation of NFκB. p62 binds to both TRAF6 (via its TBS domain) and caspase-8, and may affect both prosurvival and pro-apoptotic signaling pathways.

TRAF6 is the most diverged among the TRAF family proteins, and our studies uncovered its notable physiological and pathological functions.

2020年9月3日 · There are seven members: TRAF1-TRAF7, among those members, tumor necrosis factor receptor-associated factor 6 (TRAF6) is upregulated in various tumors, which has been related to tumorigenesis and development.

TRAF6（TNF receptor associated factor 6）是一个 泛素连接酶 （ubiquitin-ligase），当它被激活的时候，会在自身和其它蛋白上产生短小蛋白链。 因此TRAF6作为一个开关，能够决定在细胞内开启何种信号。 TGF-利用TRAF6特定地激活激酶TAK1，TAK1随后激活其它的应激活化激酶，导致细胞死亡。 研究人员表示，“发现TGF-利用TRAF6激活细胞内信号通道，为未来的研究开启了 …

2024年12月20日 · TNF receptor associated factor 6 (TRAF6) is a RING domain-containing E3 ubiquitin ligase that plays a role in adaptive and innate immunity, as well as autophagy [9]. It is also widely...

2017年6月24日 · 摘要：肿瘤坏死因子受体相关因子6（Tumor necrosis factor receptor-associated factor 6，TRAF6）是肿瘤坏死因子受体相关因子家族的一员，研究发现其在许多恶性肿瘤中高表达，并且在肿瘤细胞的增殖、迁移和凋亡过程中发挥重要作用。 随着对TRAF6与不同类型肿瘤关系的深入研究，干扰或者抑制TRAF6在与肿瘤相关信号通路中的作用或许可以为癌症治疗提供新 …