2024年12月25日 · TRAF2 (TNF Receptor Associated Factor 2) is a Protein Coding gene. Diseases associated with TRAF2 include Myeloma, Multiple and Hematologic Cancer. Among …

Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) is an intracellular adapter protein with E3 ligase activity, which interacts with a plethora of other signaling proteins, …

TNF-associated factor 2 (TRAF2), a 56kD protein, was discovered through yeast two hybrid screening for proteins interacting with the c-terminal region of human TNF receptor 2. 1 Along …

2023年4月20日 · TRAF2 (Tumor necrosis factor receptor-associated factor 2) is a dual function protein, acting as an adaptor protein and a ubiquitin E3 ligase, which plays an essential role in …

In this paper, we reveal evidence that tumor necrosis factor receptor-associated factor-2 (TRAF2), an innate immunity effector, acts as a first line of defense against cardiac myocyte cell death …

2015年4月17日 · Here, we show that TNF receptor-associated factor 2 (TRAF2)—previously implicated in apoptosis suppression—also inhibits necroptotic signaling by TNF α. TRAF2 …

2022年8月22日 · In this review, we summarize the various TRAF2-related signaling pathways and their relevance for the oncogenic and tumor suppressive activities of TRAF2. Particularly, we …

TRAF2 promotes M2-polarized tumor-associated macrophage infiltration, angiogenesis and cancer progression by inhibiting autophagy in clear cell renal cell carcinoma. The TRAF2-p62 …

2016年9月15日 · TRAF2 exerts multiple receptor-specific functions but also mediates cross-talk between TNFR1 and TNFR2, dictating the outcome of TNF stimulation. In this review, we …

2021年12月17日 · We discovered a critical role for TRAF2, an innate immunity effector protein with E3 ubiquitin ligase activity, in facilitating physiological cardiac myocyte mitophagy in the …