p63: a crucial player in epithelial stemness regulation | Oncogene
2023年10月17日 · In this review, we provide an overview of the role of p63 in epithelial stemness regulation, including self-renewal, differentiation, proliferation, and senescence. We describe …
Alveolar regeneration by airway secretory-cell-derived p63 - Cell …
Our study identifies secretory-cell-derived p63 + progenitors as contributors to alveolar repair, suggesting a potential therapeutic avenue for lung regeneration following injury. Efficient gas …
TP63 basal cells are indispensable during endoderm ... - Nature
2021年3月5日 · Here we investigated the hierarchical differentiation process of multipotent ES-derived endoderm cells into proximal airway epithelial cells on acellular lung scaffolds. The …
Autologous transplantation of P63 + lung progenitor cells for
2024年2月14日 · Adult lung resident stem/progenitor cells, including P63 + progenitor cells, have demonstrated the capacity for regeneration of lung epithelium in preclinical models. Here, we …
p63 (+)Krt5 (+) distal airway stem cells are essential for lung ...
2015年1月29日 · Correspondingly, we recently demonstrated lung regeneration in mice following H1N1 influenza virus infection, and linked distal airway stem cells expressing Trp63 (p63) and …
Derivation of Airway Basal Stem Cells from Human ... - Cell Press
Using a dual fluorescent reporter system (NKX2-1 GFP;TP63 tdTomato), we track and purify these cells as they first emerge as developmentally immature NKX2-1 GFP+ lung progenitors …
Convergence of YAP/TAZ, TEAD and TP63 activity is associated …
2023年5月8日 · In this study we examine the functional association of YAP/TAZ, TEADs and TP63 in bronchial epithelial cells and PMLs. We performed RNA-seq in primary human …
TP63 Functions as a Tumor Suppressor Regulated by GAS5/miR …
2023年2月24日 · Tumor protein p63 (TP63) has been proven to play a role as a tumor suppressor in some human cancers, including non-small cell lung cancer (NSCLC). This study aimed to …
An NKX2-1GFP and TP63tdTomato dual fluorescent reporter for …
2021年2月25日 · As TP63 is important to basal cell identity and development, we introduced the tdTomato fluorescent reporter into the human TP63 gene locus. The TP63 gene is transcribed …
ΔNp63 drives dysplastic alveolar remodeling and restricts ... - Cell …
The dramatic regulation of dysplastic remodeling and epigenetic control of lung identity by ΔNp63 expands on our knowledge of lung progenitor cell biology, plasticity, and roles in injury repair, …