2024年12月25日 · TNFRSF1A (TNF Receptor Superfamily Member 1A) is a Protein Coding gene. Diseases associated with TNFRSF1A include Periodic Fever, Familial, Autosomal Dominant and Multiple Sclerosis 5. Among its related pathways are TNFR1 Pathway and TNF signaling.

TNFRSF1A is a STAT3 target gene that regulates the NF-kappaB pathway. by restraining TNFR1 at the cell surface via sialylation, ST6Gal-I acts as a functional switch to divert signaling toward survival.

The TNFRSF1A gene provides instructions for making a protein called tumor necrosis factor receptor 1 (TNFR1). This protein is found spanning the membrane of cells, with part of the TNFR1 protein outside the cell and part of the protein inside the cell.

2025年2月8日 · TNFR1 signaling promotes pancreatic tumor growth by limiting dendritic cell number and function. Augmentation of Nitric Oxide Deficient Hypertension by High Salt Diet Is Associated With Reduced TNF-alpha Receptor Type 1 Expression in the Kidneys.

One such illness, TNF-receptor-associated periodic syndrome (TRAPS), presents with prolonged attacks of fever and severe localized inflammation. TRAPS is caused by dominantly inherited mutations in TNFRSF1A (formerly termed TNFR1), the gene encoding the 55 kDa TNF receptor.

2000年8月1日 · One such illness, TNF-receptor-associated periodic syndrome (TRAPS), presents with prolonged attacks of fever and severe localized inflammation. TRAPS is caused by dominantly inherited mutations in TNFRSF1A (formerly termed TNFR1), the gene encoding the 55 kDa TNF receptor.

Chromosome 12: 6,437,923-6,451,280 reverse strand. GRCh37:CM000674.1. This gene has 16 transcripts (splice variants), 1 paralogue and is associated with 6 phenotypes. Show transcript table.

TNFR1 is a master regulator of the inflammatory response and plays crucial roles in protecting the host from pathogen invaders including bacteria and viruses. TNFR1 belongs to a subset of receptors, called Death Receptors (DR), in the TNF superfamily.

The tumor-necrosis-factor receptor-associated periodic syndrome: new mutations in TNFRSF1A, ancestral origins, genotype-phenotype studies, and evidence for further genetic heterogeneity of periodic fevers.

2024年3月1日 · Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation.