2 天之前 · TNF inhibitors block the interaction of TNF with its two receptors, TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2). These inhibitors primarily target soluble TNF (sTNF), …

4 天之前 · The balance between TNFR1 and TNFR2 activation determines whether TNF signaling leads to inflammation, apoptosis, or tissue regeneration. Roles In Pathogen Clearance. Th1 …

3 天之前 · When reticular fibroblasts are infected by viruses, TNF-mediated signaling pathway (TNFR1, CREB3, and C/EBPβ) is activated, producing pro-inflammatory factors (IL6 and …

3 天之前 · Of the additional 250 proteins, 45 were associated with EA risk and 6 (MCP3, IL6, TNFR1, HGF, TFF3 and FURIN) remained significant after FDR correction. Conclusions: We …

4 天之前 · Collagen I and TNFR1 were identified as direct targets of miR-29a-3p in fibroblasts and endothelial cells, respectively. Exosomes overexpressing miR-29a-3p provided superior …

5 天之前 · Soluble Tumor Necrosis Factor Receptor 1 (TNFR1) normally attenuates the immune response by preventing binding of TNF-α to its membrane receptors. The lack of this soluble …

5 天之前 · Its pro-apoptotic effect activates caspase by binding to TNFR1, recruiting RIP-1, TRADD, TRAF2, FADD, and procaspase-8 to form a death-inducing signal complex (DISC), …

4 天之前 · TNFα signaling via TNFR1 exerts proinflammatory and pro-apoptotic effects, whereas signaling via TNFR2 promotes protective effects . Activation of TNFR2 anti-inflammatory …

4 天之前 · TNF controls inflammatory signaling and cell survival through binding to two distinct receptors, TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2) . TNFR2 is overexpressed in …

5 天之前 · The expression level of TNFR1 in decidual tissues of RPL patients was significantly increased, which activates p53/p16-dependent senescence signal and leads to excessive …