Transmembrane channel-like protein 1 is a protein that in humans is encoded by the TMC1 gene. [5][6][7] TMC1 contains six transmembrane domains with both the C and N termini on the …

2022年10月12日 · Here we report the single-particle cryo-electron microscopy structure of the native transmembrane channel-like protein 1 (TMC-1) mechanosensory transduction complex …

2025年2月25日 · Here, our study unveils CIB2/3’s role as a calcium sensor in its interaction with TMC1. Utilizing X-ray crystallography, we elucidate the high-resolution structure of the …

2025年2月5日 · Mammalian transmembrane channel-like proteins 1 and 2 (TMC1 and TMC2) have emerged as very promising candidate mechanotransduction channels in hair cells. …

2025年2月25日 · Recently, TMC1 and TMC2 (TMC1/2) have emerged as the pore-forming subunit of the MT channel. However, the functional study of TMC1/2 in heterologous cells has …

2024年12月25日 · TMC1 (Transmembrane Channel Like 1) is a Protein Coding gene. Diseases associated with TMC1 include Deafness, Autosomal Dominant 36 and Deafness, Autosomal …

TMC1 encodes a protein required for the normal function of mechanically-activated channels that enable sensory transduction in auditory and vestibular hair cells. TMC1 protein is localized at …

Mammalian transmembrane channel-like proteins 1 and 2 (TMC1 and TMC2) have emerged as very promising candidate mechanotransduction channels in hair cells. However, controversy …

2025年2月8日 · TMC1 has been identified as the causative gene in a six-generation Chinese family with autosomal dominant hearing loss. The first mutation in the TMC1 gene in the …

2019年1月22日 · Here, the authors use a synthetic AAV to replace TMC1 and 2 in the inner ear and show restoration of cochlear and vestibular function, of neuronal reponses in the auditory …