Toll-like receptor 4 (TLR4) belongs to the family of pattern recognition receptors (PRRs). They are highly conserved receptors that recognize conserved pathogen-associated molecular patterns (PAMPs), thus representing the first line of defense against infections.

Dec 25, 2024 · TLR4 (Toll Like Receptor 4) is a Protein Coding gene. Diseases associated with TLR4 include Macular Degeneration, Age-Related, 10 and Pertussis. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System.

Nov 24, 2023 · TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular membrane’s surface but also interacts with intracellular ligands, initiating intricate intracellular signaling cascades.

Toll-like receptor 4 (TLR4) is unique among TLRs in its ability to activate two distinct signalling pathways — one pathway is activated by the adaptors TIRAP...

May 5, 2022 · Toll-like receptor 4 (TLR4), a member of the Toll-like receptor (TLR) family, is involved in innate immunity and mediates inflammatory responses by recognizing lipopolysaccharide (LPS) or bacterial endotoxins.

Gene ID: 7099, updated on 8-Feb-2025. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities.

Toll-like receptor 4 (TLR4) is a transmembrane protein, expressed in the myeloid (erythrocytes, granulocytes, macrophages) rather than lymphoid (T-cells, B-cells, NK cells). Toll-like receptor 4 plays a fundamental role in pathogen recognition and activation of innate immunity.

Toll-like receptors (TLRs) are important pattern recognition receptors that identify the invading pathogens to activate immune inflammatory responses. TLR4 binds lipopolysaccharide (LPS) from gram-negative bacteria, particularly the fatty acyl chains in the lipid A moiety.

Feb 8, 2025 · In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19).

May 26, 2016 · Human TLR4 was the first mammalian Toll protein to be characterized and is secreted from the endoplasmic reticulum. TLR4 initiates the expression of a number of pro-inflammatory genes, cell...