Role of TL1A in Inflammatory Autoimmune Diseases: A …
Here, this study summarized information about the molecular mechanism of TL1A and discussed role of TL1A in immune cells, especially focused on association between TL1A and …
TL1A: A New Potential Target in the Treatment of Inflammatory Bowel ...
Recent studies showed that TL1A (Tumor necrosis factor-like cytokine 1A) acts as a regulator of mucosal immunity and participates in immunological pathways involved in the IBD …
Phase 2 Trial of Anti-TL1A Monoclonal Antibody Tulisokibart for ...
Sep 25, 2024 · Tulisokibart is a tumor necrosis factor–like cytokine 1A (TL1A) monoclonal antibody in development for the treatment of moderately to severely active ulcerative colitis. A …
Role of TL1A in Inflammatory Autoimmune Diseases: A ... - PubMed
Jul 14, 2022 · TL1A, also called TNFSF15, is a member of tumor necrosis factor family. It is expressed in different immune cell, such as monocyte, macrophage, dendritic cell, T cell and …
An anti-TL1A antibody for the treatment of asthma and ... - PubMed
TL1A is an attractive therapeutic target for the treatment of mucosal inflammation associated with inflammatory bowel disease (IBD) and asthma. Blockade of the TL1A pathway has been …
The TNF-family cytokine TL1A: from lymphocyte costimulator to …
Originally described in 2002 as a T cell-costimulatory cytokine, the tumor necrosis factor family member TNF-like factor 1A (TL1A), encoded by the TNFSF15 gene, has since been found to …
The tale of TL1A in inflammation | Mucosal Immunology - Nature
May 4, 2011 · TL1A (also known as TNFSF15) is a tumor necrosis factor (TNF) family member expressed by monocytes, macrophages, dendritic cells (DCs), synovial fibroblasts, and …
TL1A inhibition for inflammatory bowel disease treatment: From ...
May 10, 2024 · TL1A-DR3 interactions in animal models regulate effector T cell expansion and maintain Treg homeostasis. TL1A is implicated in initiating and enhancing responses in Th1, …
Biochemical and Structural Characterization of the Human TL1A ...
TNF-like 1A (TL1A) is a newly described member of the TNF superfamily that is directly implicated in the pathogenesis of autoimmune diseases, including inflammatory bowel disease, …
Investigational drug TEV-48574, potentially exerting dual antifibrotic and anti-in-flammatory effects, is undergoing a phase 2 basket study in both ul-cerative colitis (UC) and Crohn …
- Some results have been removed