tl1a/dr3概述. tl1a（ tnf样配体1a ）也称为tnfsf15，是 肿瘤坏死因子家族 成员。 tl1a 是一种 2 型跨膜蛋白，可通过与 tnf 同源结构域 (thd) 相互作用自组装成稳定的三聚体。

2024年9月3日 · 靶向TL1A的药物研发进展. 发展前景. 总结. 在审视TL1A靶点之际，我们的视野不应仅仅局限于炎症性肠病（IBD）的框架内，鉴于其在广泛炎症性疾病领域中展现出的巨大潜力，TL1A或许能够开启类似于“药界传奇”Humira那样的辉煌篇章。

2025年2月14日 · tl1a的异常表达与炎症性肠病、过敏性疾病和自身免疫性疾病的发生和发展密切相关。 （数据来源 Bamias G, et al. Gut. 2024） 参与纤维化过程： TL1A在肠道纤维化中发挥重要作用，能够通过DR3信号通路促进成纤维细胞的增殖和胶原蛋白的合成，从而加剧纤维化过程。

TL1A binds to the receptor DR3 and activates the TRADD pathway. The complex exerts pro-inflammatory effects by regulating downstream pathways, such as TRAF2, RIP1, PI3K, MAPKs, NF-κB, and then regulates cytokine, chemokine secretion. TL1A/DR3 is involved in promoting apoptosis and necroptotic cell death through FADD, RIP3, Caspase-8/-3/-7 ...

研究表明，tnf家族成员tl1a是肠道炎症的关键介质，tl1a主要通过结合dr3发挥其功能，tl1a还可以协同促进 il-4 、 il-12 和 il-23 的产生，并通过th1、th2和th17细胞增加dr3的表达以促进炎症。临床试验显示，与健康对照相比，ibd患者结肠组织中tl1a表达升高并与炎症的严重 ...

2024年9月25日 · In this phase 2 trial, tulisokibart, a monoclonal antibody directed against TL1A, was more effective than placebo for induction of clinical remission in patients with moderately to severely...

2022年7月14日 · TL1A, also called TNFSF15, is a member of tumor necrosis factor family. It is expressed in different immune cell, such as monocyte, macrophage, dendritic cell, T cell and non-immune cell, for example, synovial fibroblast, endothelial cell. TL1A competitively binds to death receptor 3 or decoy recept …

Recent studies showed that TL1A (Tumor necrosis factor-like cytokine 1A) acts as a regulator of mucosal immunity and participates in immunological pathways involved in the IBD pathogenesis. In this review article, we analyze the role of TL1A as a …

2024年7月3日 · 研究发现，tl1a在自免疫疾病中异常表达，并参与 类风湿性关节炎 、银屑病和炎症性肠病等自身免疫性疾病。tl1a因其独特的作用机制在炎症性反应等方面发挥重要作用。目前，tl1a已成为溃疡性结肠炎、克罗恩病等疾病的新靶点。

5 天之前 · TL1A’s expression is induced by microbial stimuli and inflammatory cytokines, linking its role to environmental cues shaping mucosal immunity. One of TL1A’s primary functions in mucosal tissues is its regulatory effect on epithelial cells, which serve as the first line of defense against external insults.