
TGFBR1 Gene - GeneCards | TGFR1 Protein | TGFR1 Antibody
2024年12月25日 · TGFBR1 (Transforming Growth Factor Beta Receptor 1) is a Protein Coding gene. Diseases associated with TGFBR1 include Multiple Self-Healing Squamous Epithelioma and Loeys-Dietz Syndrome 1. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and TGFBR2 Kinase Domain Mutants in Cancer.
TGFBR1 gene - MedlinePlus
The TGFBR1 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 1. This receptor transmits signals from the cell surface into the cell through a process called signal transduction.
TGF-β receptors: In and beyond TGF-β signaling - PubMed
Focusing on the receptors in events in and beyond TGF-β signaling, we review the membrane trafficking of TGFBRs, the kinase activity of TGFBR1 and 2, the direct interactions between TGFBR2 and other receptors, and the novel roles of TGFBR3.
TGFBR1 transforming growth factor beta receptor 1 [ (human)]
Gene ID: 7046, updated on 8-Feb-2025. The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein …
TRANSFORMING GROWTH FACTOR-BETA RECEPTOR, TYPE I; TGFBR1 …
The TGFBR1 gene encodes a serine/threonine kinase receptor for transforming growth factor-beta (TGFB1; 190180). Most growth factor receptors are transmembrane tyrosine kinases or are associated with cytoplasmic tyrosine kinases.
Transforming Growth Factor β Receptor Type 1 Is Essential for
2011年10月20日 · TGFβ type 1 receptor (TGFBR1), also known as activin receptor-like kinase 5, is the major type 1 receptor for TGFβ ligands. Tgfbr1 null mice die embryonically, precluding functional characterization of TGFBR1 postnatally.
TGFBR1 protein expression summary - The Human Protein Atlas
This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and …
Pathogenic effect of a TGFBR1 mutation in a family with …
Our findings confirm the pathogenic effect of the TGFBR1 mutation in causing TAAD in Loeys–Dietz syndrome and show increased myogenic differentiation of patient fibroblasts. Keywords: Loeys–Dietz syndrome, Myogenic transdifferentiation of fibroblasts, Smooth muscle‐like cells, TGFBR1 mutation, Thoracic aortic aneurysm and aortic ...
TGFBR1 transforming growth factor beta receptor 1 [Homo …
2025年2月20日 · Title: TGFβR1 inhibition drives hepatocellular carcinoma proliferation through induction of toll-like-receptor signalling. Exosomes from human adipose-derived mesenchymal stem cells attenuate localized scleroderma fibrosis by the let-7a-5p/TGF-betaR1/Smad axis.
TGFBR1 transforming growth factor beta receptor 1
2025年1月4日 · Go to complete Gene record for TGFBR1; Go to Variation Viewer for TGFBR1 variants; Summary. The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase.
- 某些结果已被删除