TGF beta signaling pathway - Wikipedia
The transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, cell migration, apoptosis, cellular homeostasis and other cellular functions.
TGF-β signaling in health, disease and therapeutics
2024年3月22日 · In this review, we retrace the research history of TGF-β and introduce the molecular mechanisms regarding its biosynthesis, activation, and signal transduction. We also provide deep insights...
TGF-β Signaling - PMC
At the plasma membrane level, TGF-βs associate with receptor kinases that mediate phosphorylation-dependent signaling to downstream mediators, mainly the SMAD proteins, and mediate oligomerization-dependent signaling to ubiquitin ligases and intracellular protein kinases.
TGFβ signalling in context - Nature Reviews Molecular Cell Biology
2012年9月20日 · TGFβ receptors signal through the canonical SMAD pathway that controls the expression of hundreds of genes, and several non-canonical pathways that regulate cell polarity, the cytoskeleton...
TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and …
The transforming growth factor-β (TGF-β) is the prototype of the TGF-β family of growth and differentiation factors, which is encoded by 33 genes in mammals and comprises homo- and heterodimers. This review introduces the reader to the TGF-β family ...
TGFβ signaling pathways in human health and disease - PMC
TGFβ initiates signaling by assembling receptor complexes that activate SMAD transcription factors. Phosphorylated Smad2/3 proteins form a trimeric complex with Smad4, translocate into the nucleus, and regulate gene expression. Different connective tissue diseases associated with specific TGFβ signaling effectors are indicated in black boxes.
TGF-β Family Signaling in the Control of Cell Proliferation and ...
2017年4月3日 · The transforming growth factor β (TGF-β) family controls many fundamental aspects of cellular behavior. With advances in the molecular details of the TGF-β signaling cascade and its cross talk with other signaling pathways, we now have a more coherent understanding of the cytostatic program induced …
TGF-β signaling: A recap of SMAD-independent and SMAD-dependent pathways
TGF-β serves as an antiproliferative agent and inhibits tumor development during primary stages of tumor progression; however, during the later stages, it encourages tumor development and mediates metastatic progression and chemoresistance.
TGF-β signaling in health and disease - Cell Press
2023年9月14日 · The TGF-β pathway epitomizes membrane-to-nucleus signaling by direct receptor-mediated activation of TFs (Figure 2C). The receptor subunit composition, ligand-driven activation mechanism, and signal propagation through SMAD proteins elucidated for TGF-β apply to the rest of the TGF-β family.
TGF-beta signal transduction: biology, function and therapy for ...
2022年12月19日 · The transforming growth factor beta (TGF-β) is a crucial cytokine that get increasing concern in recent years to treat human diseases. This signal controls multiple cellular responses during embryonic development and tissue homeostasis through canonical and/or noncanonical signaling pathways.
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