
TGF-β signaling in health, disease and therapeutics
2024年3月22日 · In this review, we retrace the research history of TGF-β and introduce the molecular mechanisms regarding its biosynthesis, activation, and signal transduction. We also …
TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and …
The transforming growth factor-β (TGF-β) is the prototype of the TGF-β family of growth and differentiation factors, which is encoded by 33 genes in mammals and comprises homo- and …
TGF-beta signal transduction: biology, function and therapy for ...
2022年12月22日 · Dysregulated TGF-β signal plays an essential role in contributing to fibrosis via promoting the extracellular matrix deposition, and tumor progression via inducing the epithelial …
TGF-β Signaling - PMC
Transforming growth factor-β (TGF-β) represents an evolutionarily conserved family of secreted polypeptide factors that regulate many aspects of physiological embryogenesis and adult …
TGF-β Signaling - PubMed
2020年3月23日 · Transforming growth factor-β (TGF-β) represents an evolutionarily conserved family of secreted polypeptide factors that regulate many aspects of physiological …
TGF-β receptors: In and beyond TGF-β signaling - PubMed
Transforming growth factor β (TGF-β) plays an important role in normal development and homeostasis. Dysregulation of TGF-β responsiveness and its downstream signaling pathways …
TGF-β signaling in health and disease - Cell Press
2023年9月14日 · TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury repair through coordinated effects on cell proliferation, phenotypic plasticity, …
TGF-β – an excellent servant but a bad master | Journal of ...
2012年9月3日 · Transforming Growth Factor-β (TGF-β) is a key player in cell proliferation, differentiation and apoptosis. The importance of this regulation is apparent from the role of …
TGF-β: the master regulator of fibrosis - Nature
2016年4月25日 · Transforming growth factor-β (TGF-β) is a key driver of fibrosis in chronic kidney disease, acting via canonical and non-canonical signalling pathways to activate myofibroblasts …
The TGF-b regulatory system plays crucial roles in the preservation of organismal integrity. TGF-b signaling controls metazoan embryo development, tissue homeostasis, and injury repair …
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