Transcription factor II H (TFIIH) is an important protein complex, having roles in transcription of various protein-coding genes and DNA nucleotide excision repair (NER) pathways.

2012年5月10日 · TFIIH is a multiprotein complex that is involved in various cellular processes, including nucleotide excision repair (NER) and transcription, revealing the tight molecular connections between...

We describe the structure of TFIIH and its roles in pol II initiation, promoter‐proximal pausing, elongation, and termination. We also discuss cellular roles for TFIIH beyond transcription (e.g. DNA repair, cell cycle regulation) and summarize small molecule inhibitors of TFIIH and diseases associated with defects in TFIIH structure and function.

Transcription factor IIH (TFIIH) is a multiprotein complex involved in both eukaryotic transcription and DNA repair, revealing a tight connection between these two processes. Composed of 10 subunits, it can be resolved into a 7-subunits core complex with the XPB translocase and the XPD helicase, and …

2011年9月28日 · TFIIH is a basal or general transcription factor of RNA polymerase II and necessary for the transcription of every protein-coding gene. TFIIH is composed of 10 subunits with three enzymatic activities, the ATP-dependent helicases XPB and XPD and the CAK sub-complex with the kinase cdk7.

TFIIH is a multisubunit basal transcription factor that also functions in nucleotide excision repair. The recent discoveries of some small molecules that interfere with TFIIH and that preferentially kill cancer cells have increased researchers' interest to elucidate the complex mechanisms by which TFIIH operates.

2025年3月8日 · TFIIH comprises ten protein subunits—seven forming core TFIIH (XPD, XPB, p44, p34, p8, p62, and p52) and three forming the CAK subcomplex (MAT1, Cdk7, and Cyclin H) 30,31. While CAK is key for ...

Transcription factor IIH (TFIIH) is a heterodecameric protein complex critical for transcription initiation by RNA polymerase II and nucleotide excision DNA repair. The TFIIH core complex is sufficient for its repair functions and harbors the XPB and XPD DNA-dependent ATPase/helicase subunits, which are affected by human disease mutations.

This review focuses on the major cellular roles for TFIIH, with an emphasis on TFIIH function as a regulator of pol II transcription. We describe the structure of TFIIH and its roles in pol II initiation, promoter-proximal pausing, elongation, and termination.

2023年5月13日 · Mapping TFIIH disease mutations onto network models reveals clustering into distinct mechanistic classes, affecting translocase functions, protein interactions and interface dynamics.