Transcription factor E3 is a protein that in humans is encoded by the TFE3 gene. [5][6][7] TFE3, a member of the helix-loop-helix family of transcription factors, binds to the mu-E3 motif of the immunoglobulin heavy-chain enhancer and is expressed in many cell types (Henthorn et al., 1991). [supplied by OMIM] [7]

2024年12月25日 · TFE3 (Transcription Factor Binding To IGHM Enhancer 3) is a Protein Coding gene. Diseases associated with TFE3 include Intellectual Developmental Disorder, X-Linked, Syndromic, With Pigmentary Mosaicism And Coarse Facies and …

2022年5月23日 · TFE3 fusions are most closely associated with Xp11 translocation renal cell carcinoma, alveolar soft part sarcoma, melanotic Xp11 renal cell carcinoma, some PEComas and others. Although increased TFE3 expression is seen in some solid pseudopapillary pancreatic neoplasms, these have been negative for the gene fusion.

2024年12月17日 · TFE3 rearranged renal cell carcinoma (TFE3 rRCC) is the most common subtype of renal cell carcinoma within the MiT translocation family.

Transcription factor binding to IGHM enhancer 3 (TFE3) is a gene that encodes a protein that promotes the expression of genes downstream of transforming growth factor beta signaling.

What is TFE3-Associated Neurodevelopmental Disorder (TFE3)? TFE3 is a condition which can cause severe intellectual disability, differences in the development of facial features and pigmentary mosaicism (varied patterns of pigmentation in the skin).

3 天之前 · Boosting TFE3 levels reversed autophagy defects observed in dopamine-producing neurons as a consequence of alpha-synuclein accumulation. This increase in TFE3 also promoted the clearance of alpha-synuclein clumps and inhibited their spread throughout the brain.

2021年10月26日 · TFE3, a member of the helix-loop-helix family of transcription factors, binds to the mu-E3 motif of the immunoglobulin heavy-chain enhancer and is expressed in many cell types (Henthorn et al., 1991). Macchi et al. (1995) cloned the TFE3 gene.

2018年12月6日 · Here we demonstrate that DNA damage activates TFE3 and TFEB in a p53 and mTORC1 dependent manner. RNA-Seq analysis of TFEB/TFE3 double-knockout cells exposed to etoposide reveals a profound dysregulation of the DNA damage response, including upstream regulators and downstream p53 targets.

2025年3月3日 · The findings reveal that TFE3 activation facilitates the clearance of toxic alpha-synuclein aggregates and restores mitochondrial function, two crucial aspects of PD progression.