TDP-43 is a widely expressed nuclear protein that binds both DNA and RNA. While shuttling between nucleus and cytoplasm, it helps regulate many aspects of RNA processing, such as …

Mar 6, 2018 · Consistent with TDP-43 autoregulation, a decrease in endogenous murine levels was observed in transgenic mice. Transgene expression was highest in the brain and spinal …

Jan 9, 2018 · Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy. Neuropathology. 2010 …

Mar 6, 2018 · Protein levels of human TDP-43 were highest in the brain, spinal cord, and muscle, with lower levels in the liver and kidney, mimicking endogenous expression patterns. Despite …

Sep 9, 2020 · The TDP-43 construct lacked a nuclear localization signal, keeping it cytoplasmic. Again, poly(GR) aggregated with TDP-43, but poly(GA) did not (see image above). By …

Mar 6, 2018 · The cytotoxic 25 kDA C-terminal fragment of TDP-43 also increased in an age-dependent manner in both the brain and spinal cord. Evidence of cytoskeletal abnormalities …

Sep 21, 2018 · Transgenic human TDP-43 is expressed in the brains and spinal cords of TAR6/6 mice at levels similar to the endogenous mouse protein (Wils et al., 2010; Scherz et al., 2018). …

Feb 4, 2016 · TDP-43 (Wt-TAR6/6) Paper Citations. Wils H, Kleinberger G, Janssens J, Pereson S, Joris G, Cuijt I, Smits V, Ceuterick-de Groote C, Van Broeckhoven C, Kumar-Singh S. TDP …

Oct 31, 2024 · To investigate TDP-43 proteinopathy, joint first authors Muzi Du and Suleyman Akerman turned to a mouse model first developed by Leonard Petrucelli at the Mayo Clinic in …

Jun 5, 2019 · TDP-43 protein was primarily nuclear, however, some cytoplasmic TDP-43 was observed in neurons of the spinal cord, brainstem, and cortex. Phosphorylated TDP-43 (at …