TDP-43 is a widely expressed nuclear protein that binds both DNA and RNA. While shuttling between nucleus and cytoplasm, it helps regulate many aspects of RNA processing, such as …

2018年3月6日 · Consistent with TDP-43 autoregulation, a decrease in endogenous murine levels was observed in transgenic mice. Transgene expression was highest in the brain and spinal …

2019年5月1日 · Instead, TDP-43 inclusions crowd her limbic regions. This would be a typical case of limbic-predominant age-related TDP-43 encephalopathy (LATE), a common …

2018年3月6日 · Protein levels of human TDP-43 were highest in the brain, spinal cord, and muscle, with lower levels in the liver and kidney, mimicking endogenous expression patterns. …

2020年9月9日 · The TDP-43 construct lacked a nuclear localization signal, keeping it cytoplasmic. Again, poly(GR) aggregated with TDP-43, but poly(GA) did not (see image above). By …

2018年1月9日 · Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy. Neuropathology. 2010 …

2018年3月6日 · The cytotoxic 25 kDA C-terminal fragment of TDP-43 also increased in an age-dependent manner in both the brain and spinal cord. Evidence of cytoskeletal abnormalities …

2016年2月4日 · TDP-43 (Wt-TAR6/6) Paper Citations. Wils H, Kleinberger G, Janssens J, Pereson S, Joris G, Cuijt I, Smits V, Ceuterick-de Groote C, Van Broeckhoven C, Kumar …

2024年10月31日 · To investigate TDP-43 proteinopathy, joint first authors Muzi Du and Suleyman Akerman turned to a mouse model first developed by Leonard Petrucelli at the Mayo Clinic in …

2019年6月5日 · TDP-43 protein was primarily nuclear, however, some cytoplasmic TDP-43 was observed in neurons of the spinal cord, brainstem, and cortex. Phosphorylated TDP-43 (at …