Antigen identification for HLA class I– and HLA class II ... - AAAS
Identification of the peptide-MHC ligands recognized by a specific T cell receptor (TCR) remains a formidable bottleneck for T cell biology.
HLA-class II restricted TCR targeting human papillomavirus
2024年3月13日 · Here, we report the identification of a TCR (10F04), which is human leukocyte antigen (HLA)-DRA/DRB1*09:01 restricted and human papillomavirus type 18 (HPV18) E7 84 …
T cell receptor therapeutics: immunological targeting of the ...
2023年10月27日 · Herein, we review the current cancer treatment landscape using TCRs and TCR-like molecules. This includes adoptive cell transfer of T cells expressing endogenous or …
TCR-engineered T cell therapy in solid tumors: State of the
2023年2月15日 · HLA-negative tumor cells would be positively selected during TCR-T treatment. Loss of HLA heterozygosity (HLA LOH) was recently described in two clinical trials using TILs …
A systematic safety pipeline for selection of T-cell receptors to …
2023年8月22日 · Isolation of TCRs from populations of allogeneic T cells carries the risk that TCR-Ts might recognize HLA-A*02:01 in complex with peptides other than the intended target.
Antigen identification for HLA class I- and II-restricted T cell ...
2021年1月1日 · We engineered APCs to express anti-cytokine antibodies, a library of DNA-encoded peptides, and multiple HLA class I or II molecules. We demonstrate that these …
T-FINDER: A highly sensitive, pan-HLA platform for functional T …
2024年2月2日 · Here, we present T-FINDER [T cell Functional Identification and (Neo)-antigen Discovery of Epitopes and Receptors], a system to rapidly deconvolute CD4 and CD8 TCRs …
IMMUNOPHARMACOGENOMICS: MECHANISMS OF HLA …
Stable interaction of HLA-antigen and TCR initiates a complex intracellular signalling cascade resulting in T-cell activation. Briefly, lymphocyte-specific protein tyrosine kinase (LCK) is …
T cell receptor interactions with human leukocyte antigen …
2020年8月8日 · T cell-mediated immunity is governed primarily by T cell receptor (TCR) recognition of peptide-human leukocyte antigen (pHLA) complexes and is essential for …
Predicting Cross-Reactivity and Antigen Specificity of T Cell …
We discuss current experimental and computational approaches to investigate cross-reactivity and antigen-specificity of TCRs and highlight how integrating kinetic, biophysical and structural …
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