tert-Butyldiphenylsilyl, also known as TBDPS, is a protecting group for alcohols. Its formula is C 16 H 19 Si-. [1] The tert -butyldiphenylsilyl group was first suggested as a protecting group by Hanessian and Lavallée in 1975. It was designed to supersede the use of Corey's tert -butyldimethylsilyl as a protecting group for alcohols:

2021年10月6日 · The tert -butyldiphenylsilyl (TBDPS) protection has been commonly used for primary hydroxyl groups in carbohydrate chemistry (1). A primary hydroxyl group can be preferentially silylated using TBDPSCl and imidazole in …

Various tert -butyldimethylsilyl (TBDMS) ethers as well as tert -butyldiphenylsilyl (TBDPS) ethers can be easily deprotected by employing a catalytic amount of acetyl chloride in dry MeOH in good yields. This mild and convenient method tolerates various other protecting groups and does not lead to acylated or chlorinated byproducts.

2021年5月25日 · Functionalized small molecules that differ in only one functional group are useful molecular systems for model studies on reactivity and chemoselectivity. Straightforward synthetic routes towards three crystalline tert -butyldiphenylsilanes (TBDPS) are presented and their crystal packing is analyzed with regard to weak intermolecular interactions.

Glycerol polymers are attracting increased attention due to the diversity of polymer compositions and architectures available. This article provides a brief chronological review on the current status of these polymers along with representative examples of their use for biomedical applications.

1993年6月11日 · Reaction of the alcohol and tBDPSCl in DMF with AgN03, NH4NO3, or NH4C104 provides good yields of the corresponding silyl ethers.

12 h (entry 15). Gratifyingly, no detectable loss of the TBDPS ether or olefin isomerization occurs with the use of DMP. These results suggest that this protocol may be useful

Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety.

Two formal syntheses and one total synthesis of fostriecin (1) have been achieved, as well as, the synthesis of its related congener dihydro-dephospho-fostriecin. All the routes use the Sharpless dihydroxylation to set the absolute stereochemistry at C -8/9 positions and a Leighton allylation to set the C -5 position of the natural product.