The protein encoded by the TAS1R1 gene is a G protein-coupled receptor with seven trans-membrane domains and is a component of the heterodimeric amino acid taste receptor T1R1+3.

2023年12月13日 · Here, we report five previously uncharacterized TAS1R members in vertebrates, TAS1R4, TAS1R5, TAS1R 6, TAS1R7 and TAS1R8, based on genome-wide …

2017年5月23日 · Here we present crystal structures of the extracellular ligand-binding domains (LBDs), the taste recognition regions of the fish T1r2-T1r3 heterodimer, bound to different …

2019年6月30日 · Here, using homology modeling, molecular docking and molecular dynamics (MD) simulations, we investigate the effects of five natural umami ligands on the structural …

2012年9月28日 · We identify the G protein-coupled receptor (GPCR) T1R1/T1R3 as a direct sensor of the fed state and amino acid availability. Knocking down this receptor, which is found …

2002年2月24日 · Here we identify and characterize a mammalian amino-acid taste receptor. This receptor, T1R1+3, is a heteromer of the taste-specific T1R1 and T1R3 G-protein-coupled …

2024年12月25日 · TAS1R1 (Taste 1 Receptor Member 1) is a Protein Coding gene. Diseases associated with TAS1R1 include Dental Caries and Polycystic Kidney Disease 1. Among its …

There are three proteins in the family, T1R1, T1R2, and T1R3, encoded by their respective genes, Tas1r1, Tas1r2, and Tas1r3. T1R2 combines with T1R3 to form a heterodimer that binds with …

In this research, we identified the expression of taste receptor type 1 member 1 (T1R1) and taste receptor type 1 member 3 (T1R3) in a subset of hepatic NK cells in a mouse HCC model. …

Functional expression of T1Rs in human embryonic kidney (HEK)-293 cells revealed that different combinations of T1Rs respond to sweet and umami taste stimuli (6, 7). T1R2 and T1R3, when …