Generation and function of progenitor T cells from StemRegenin …
2019年10月16日 · We previously showed that progenitor T (proT) cells generated in vitro from HSPCs accelerated T-cell reconstitution and restored immunity after hematopoietic stem cell …
Progenitor T-cell differentiation from hematopoietic stem cells …
2017年4月10日 · This paper describes a fully defined, nonxenogeneic in vitro niche for the differentiation of haematopoietic stem and progenitor cells to progenitor T cells in mouse and …
Progenitor T-cell differentiation from hematopoietic stem cells …
The molecular and cellular signals that guide T-cell development from hematopoietic stem and progenitor cells (HSPCs) remain poorly understood. The thymic microenvironment integrates …
The epigenetic landscape of fate decisions in T cells
2025年3月19日 · Specialized T cell subsets mediate adaptive immunity in response to cytokine signaling and specific transcription factor activity. The epigenetic landscape of T cells has an …
Targeting P4HA1 promotes CD8 + T cell progenitor expansion …
2025年2月10日 · We propose that P4HA1 induction in CD8 + T cells in cancer orchestrates an immune-escape program, offering a T cell-directed target for system immunotherapy in solid …
Innate Lymphoid Cell Development: A T Cell Perspective - Cell Press
Innate lymphoid cells (ILCs) and T cells differentiate from hematopoietic stem cells (HSCs) via a common lymphoid progenitor (CLP) in bone marrow. The cell commitment of T cells and ILCs …
Stem-like memory and precursors of exhausted T cells share a …
2025年1月31日 · Here, we demonstrate that during acute infection, the transcriptional regulator inhibitor of DNA binding 3 (ID3) identifies stem-like T cells that are uniquely adapted to …
T Cell Maturation: Stages and Steps of Immune Development
2025年3月17日 · T cell development begins with hematopoietic stem cells (HSCs) in the bone marrow, which give rise to common lymphoid progenitors (CLPs). These progenitors migrate …
T Cell Development: From T-Lineage Specification to Intrathymic ...
These cells are represented within the CD34 + CD1a − T cell progenitor population (Blom and Spits 2006; Haynes et al. 1988; Kurtzberg et al. 1989), and they can differentiate into T cells …
T-Cell Differentiation from Hematopoietic Progenitor Cells Using …
2024年6月22日 · These components are instrumental in directing T-cell development while inhibiting alternative lineage differentiation. Our work led to the identification of a hydrogel …