Suramin - Wikipedia
Suramin is a reversible and competitive protein tyrosine phosphatase (PTPases) inhibitor, also is the potent inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp).
Suramin for Autism Update: 2023 and Beyond - The BRAIN …
An exclusive interview with Howard Weisman, CEO of PaxMedica, on the latest developments and plans for FDA approval for suramin, a potential breakthrough treatment for autism.
Suramin: Parasite Uses, Warnings, Side Effects, Dosage - MedicineNet
Suramin is an intravenous (IV) medication used to treat sleeping sickness or African trypanosomiasis caused by microscopic parasites of the species Trypanosoma brucei. Suramin may cause severe hypersensitivity reactions (shock and loss of consciousness).
100 Years of Suramin - PMC - PubMed Central (PMC)
Suramin is 100 years old and is still being used to treat the first stage of acute human sleeping sickness, caused by Trypanosoma brucei rhodesiense. Suramin is a multifunctional molecule with a wide array of potential applications, from parasitic and viral diseases to …
Suramin (injection route) - Mayo Clinic
2024年1月31日 · Suramin is used in the treatment of African sleeping sickness (African trypanosomiasis) and river blindness (onchocerciasis), infections caused by parasites. This medicine works by causing the parasites to lose energy, which causes their death.
Suramin: Side Effects, Uses, Dosage, Interactions, Warnings - RxList
Suramin is used to treat trypanosomiasis and T.b. gambiense. Learn about side effects, dosages, drug interactions, warnings, and more.
Researchers Studying Century-Old Drug in Potential New …
2017年5月26日 · In a small, randomized Phase I/II clinical trial (SAT1), researchers at University of California San Diego School of Medicine say a 100-year-old drug called suramin, originally developed to treat African sleeping sickness, was safely administered to children with autism spectrum disorder (ASD), who subsequently displayed measurable, but ...
Suramin Advanced Patient Information - Drugs.com
Suramin is used in the treatment of African sleeping sickness (African trypanosomiasis) and river blindness (onchocerciasis), infections caused by parasites. This medicine works by causing the parasites to lose energy, which causes their death.
Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin
2021年3月5日 · Here we report that suramin, a 100-year-old drug, is a potent inhibitor of the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) and acts by blocking the binding of RNA to the enzyme.
Suramin | C51H40N6O23S6 | CID 5361 - PubChem
Suramin's action in the treatment of onchocerciasis is macrofilaricidal and partially microfilaricidal. It may also act as an antagonist of P2 receptors and as an agonist of Ryanodine receptors. It also can inhibit follicle-stimulating hormone receptors.