Supersaturation is important because it is the driving force for both crystal nucleation and growth. The control of supersaturation is key to attaining desired product attributes, especially final crystal size distribution and phase.

2020年2月4日 · Crystallization is a collection of the subprocesses of crystal primary nucleation, crystal growth, secondary nucleation and agglomeration, which are all governed by the prevailing supersaturation as well as other parameters. The rates of these subprocesses determine the crystalline product quality.

2023年3月16日 · We investigated the crystallization fouling of BaSO 4 at 10 different supersaturations (saturation ratios from 6.6 to 457.1). We show that deposition behavior changes from a growth-dominated regime to a nucleation-dominated regime as the supersaturation increases; these changes in the dominant regime affect the resilience of the surface deposits.

2022年2月3日 · Crystallization from a supersaturated solution is one method of increasing chemical purity, as the crystal excludes many contaminants. Some drugs are supersaturated in a solvent to allow precise doses or deliver drugs that have only low solubility in water.

A supersaturated solution is unstable, and by seeding it you can trigger rapid crystallization. How it works: Sodium acetate can dissolve in water in great quantities at high temperature, and if you let the solution cool carefully to around room temperature, you have a …

2012年5月1日 · In this paper, the relationships between supersaturation and crystal qualities are discussed, and the operation design methods are introduced to control crystal qualities in solution crystallization.

This paper reviews the basic thermodynamic derivation of the supersaturation expression, revisits common simplifying assumptions, and discusses the shortcomings of those assumptions for the design of industrial crystallization processes.

2015年7月5日 · In this chapter we will show how phase diagrams help to select a crystallization method, and to determine the yield and the temperature of a crystallization process. The industrially relevant features of the main crystallization methods are also presented.

Supersaturation occurs when a solution contains more solute than should be possible thermodynamically, given the conditions of the system. Supersaturation is considered a major driver for crystallization.

Supersaturation is the quantity of solute present in a solution (in which crystals are growing) compared with the quantity of solute that is in equilibrium with the solution. The supersaturation is expressed as a coefficient, given as, S = (Parts solute/100 parts solvent) at prevailing condition/(Parts solute/100 parts solvent) at equilibrium > 1.0