STUB1 (STIP1 homology and U-Box containing protein 1) is a human gene that codes for the protein CHIP (C terminus of HSC70-Interacting Protein). [5] [6]

2024年12月25日 · Complete information for STUB1 gene (Protein Coding), STIP1 Homology And U-Box Containing Protein 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

2023年9月1日 · STUB1 is a novel synergistic molecular chaperone with ubiquitinase activity that mediates the degradation of intracellular misfolded proteins, essential for maintaining intracellular homeostasis.

2022年4月8日 · STUB1 mediates ubiquitination-dependent proteasomal degradation of IFNγ-R1/JAK1 complex through IFNγ-R1 K285 and JAK1 K249. Conversely, STUB1 inactivation amplifies IFNγ signaling, sensitizing...

It has recently been discovered that the E3 ubiquitin ligase STIP1 homology and U-box–containing protein 1 (STUB1 or CHIP) is up-regulated during the senescence of human fibroblasts and modulates cell senescence. However, the molecular mechanism underlying STUB1-controlled senescence is not clear.

2018年11月16日 · STUB1 is a co-chaperone protein and functional E3 ubiquitin ligase that links HSP70’s polypeptide-binding activity to the ubiquitin proteasome system. HSP70 interacts with STUB1 and...

2024年11月26日 · We demonstrated that E3 ubiquitin ligase STUB1 directly interacted with NSUN2 and catalyzed ubiquitination mainly at NSUN2 K437 and K654 sites with Hsp70 as the co-factor. STUB1-mediated ubiquitination and degradation of NSUN2 was promoted in …

2022年8月18日 · Genetic deletion of STUB1 increased IFNGR1 abundance on the cell surface and thus enhanced the downstream IFNγ response as showed by multiple approaches including Western blotting, flow...

This review provides a comprehensive overview of STUB1's role in cancer, including its clinical significance, impact on tumor progression, dual roles, tumor stem cell-like properties, angiogenesis, drug resistance, and DNA repair.

STUB1, or CHIP, is an E3 ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of misfolded chaperone protein substrates for proteasomal degradation (Min et al., 2008, summary by Cocozza et al., 2020).