Stobbe condensation - Wikipedia
The Stobbe condensation entails the reaction of an aldehyde or ketone with an ester of succinic acid to generate alkylidene succinic acid or related derivatives. [1] The reaction consumes one equivalent of metal alkoxide.
Stobbe Condensation: Definition, Examples, Reagents and …
2024年12月5日 · Stobbe Condensation is used to substitute a propionic acid residual for the carbonyl group in aromatic ketones. When combined with the Friedel-Crafts reaction, this condensation can yield naphthols, indones, and tetralones.
Stobbe Condensation - an overview | ScienceDirect Topics
Stobbe condensation is defined as the reaction between aldehydes/ketones and esters of succinic acid in the presence of a basic catalyst, resulting in the formation of alkylidene succinic acid or its isomers through tautomeric shift.
All about Stobbe reaction - Unacademy
The Stobbe condensation, known commonly as the succinic esters condensation, is an organic chemistry reaction. In 1893, Hans Stobbe discovered this synthesis. When esters condense with aldehydes or ketones in a strong base, this is referred to as a specific case of condensation.
What is Stobbe Condensation - Unacademy
Stobbe condensation is the reaction of aldehydes or ketones with an ester of succinic acid to produce alkylidene succinic acid or isomers generated by a tautomeric transfer of hydrogen. The primary product is the salt of the half-ester, which requires one mole of metal alkoxide per mole of carbonyl chemical and ester.
The Stobbe Condensation - Johnson - Wiley Online Library
2011年3月15日 · The reaction of aldehydes or ketones with an ester of succinic acid to form alkylidenesuccinic acid, or isomers formed by a tautomeric shift of hydrogen, is known as the Stobbe condensation. One mole of metal alkoxide is required per mole of carbonyl compound and ester, and the primary product is the salt of the half-ester.
STUDIES ON STOBBE CONDENSATION: REACTIONS OF …
Benzaldehyde, o -methoxybenzaldehyde, p -chlorobenzaldehyde, benzophenone, and acetophenone are condensed with dimethyl methylsuccinate in the presence of potassium tert -butoxide to give the corresponding β-half-esters. In the case of o -methoxybenzaldehyde the lactonic acid (IX) is also obtained.
The Stobbe Condensation - Organic Reactions
The reaction of aldehydes or ketones with an ester of succinic acid to form alkylidenesuccinic acid, or isomers formed by a tautomeric shift of hydrogen, is known as the Stobbe condensation. One mole of metal alkoxide is required per mole of carbonyl compound and ester, and the primary product is the salt of the half-ester.
The first step of the Stobbe condensation is the formation of the enolate anion 2(i) of the succinic ester 2 which attacks the benzaldehyde 1 to yield the lactone 2 (iv) through the vias...
Stobbe Condensation - Major Reference Works - Wiley Online …
2010年9月15日 · The Stobbe condensation is a strong base (e.g., NaOEt) promoted condensation between a ketone (or aldehyde) and a dialkyl ester of diacid (e.g., succinate) in an alcoholic solution to form a half ester of the substituted itaconate.