STMN2 Gene - GeneCards | STMN2 Protein | STMN2 Antibody
Dec 25, 2024 · STMN2 (Stathmin 2) is a Protein Coding gene. Diseases associated with STMN2 include Trichorhinophalangeal Syndrome, Type Ii and Creutzfeldt-Jakob Disease . Among its …
STMN2 - Wikipedia
Stathmin-2 is a protein that in humans is encoded by the STMN2 gene. [5][6][7] Superior cervical ganglion -10 is a neuronal growth-associated protein which shares significant amino acid …
Loss of Stathmin-2, a hallmark of TDP-43-associated ALS ... - Cell …
Constitutive STMN2 loss results in early-onset sensory and motor neuropathy featuring impaired motor behavior and dramatic distal neuromuscular junction (NMJ) denervation of fast-fatigable …
What Is the Role of Stathmin-2 in Axonal Biology and Degeneration?
Aug 16, 2021 · Stathmin-2 (STMN2) is a microtubule-associated protein that has a major role in axonal development and repair. STMN2 promotes microtubule instability necessary for normal …
Loss of mouse Stmn2 function causes motor neuropathy - Cell Press
Mar 15, 2022 · Both mosaic founders and homozygous loss-of-function Stmn2 mice exhibited neuromuscular junction denervation and fragmentation, resulting in muscle atrophy and …
ALS-implicated protein TDP-43 sustains levels of STMN2, a ... - Nature
Jan 14, 2019 · We propose that restoring STMN2 expression warrants examination as a therapeutic strategy for ALS. ALS is a neurodegenerative disease characterized by the loss of …
Novel STMN2 Variant Linked to Amyotrophic Lateral Sclerosis Risk …
We report a novel non-coding CA repeat in Stathmin-2 which is associated with sALS disease risk and has disease modifying effects. The potential value of this variant as a disease marker and …
STMN2 stathmin 2 [Homo sapiens (human)] - Gene - NCBI
Feb 9, 2025 · Title: STMN2 mediates nuclear translocation of Smad2/3 and enhances TGFβ signaling by destabilizing microtubules to promote epithelial-mesenchymal transition in …
Stathmin-2 loss leads to neurofilament-dependent axonal collapse ...
Nov 23, 2023 · Persistent stathmin-2 loss in adult mice results in pathologies found in ALS, including reduced interneurofilament spacing, axonal caliber collapse that drives tearing within …
Stress-induced TDP-43 nuclear condensation causes splicing loss …
Jul 23, 2024 · Stress-induced nuclear condensation transiently inactivates TDP-43, leading to loss of interaction with its protein binding partners and loss of function in splicing. Splicing changes …