Apr 11, 2023 · Here, we report broad expression of STEAP1 relative to prostate-specific membrane antigen (PSMA) in lethal metastatic prostate cancers and the development of a STEAP1-directed chimeric...

Oct 15, 2023 · STEAP1 is now drawing attention as a promising therapeutic target because of its tumor specificity and membrane-bound localization. The clinical efficacy of an antibody-drug conjugate targeting STEAP1 in metastatic, castration-resistant, prostate cancer was demonstrated in a phase 1 trial.

Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene. [5] This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines.

Jan 12, 2024 · Xaluritamig (AMG 509) is a six-transmembrane epithelial antigen of the prostate 1 (STEAP1)-targeted T-cell engager designed to facilitate lysis of STEAP1-expressing cancer cells, such as those in advanced prostate cancer.

• STEAP1 is a membrane protein that is overexpressed in > 80% of prostate cancers, representing an attractive target for treating mCRPC 11-13 • Several modalities are being investigated to target STEAP1 11,17

May 1, 2012 · STEAP1 actively increases intra- and intercellular communication through the modulation of Na +, Ca 2+, and K + concentration, as well as the concentration of small molecules. It stimulates cancer cell proliferation and tumor invasiveness.

STEAP1 and STEAP1B gene share high homology and are differentially expressed in human prostate cell lines. A detailed in silico analysis allowed to compare the genomic organization of STEAP1 and STEAP1B genes.

The expression of STEAP1 is associated with higher Gleason scores and a worse prognosis in prostate cancer patients. STEAP1 is only minimally expressed in normal tissues, including the normal prostate, which makes it an ideal therapeutic target.

STEAP1, in particular, is highly expressed on the plasma membrane of prostate cancer cells and has received significant attention as a potential therapeutic target. This review highlights what is known about STEAP1–4 and identifies knowledge gaps that require further research.

Jan 4, 2025 · STEAP1 facilitates metastasis and epithelial-mesenchymal transition of lung adenocarcinoma via the JAK2/STAT3 signaling pathway. Cryo-electron microscopy structure and potential enzymatic function of human six-transmembrane epithelial antigen …