2023年4月11日 · Here, we report broad expression of STEAP1 relative to prostate-specific membrane antigen (PSMA) in lethal metastatic prostate cancers and the development of a …

Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene. [5] This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple …

2024年1月12日 · Xaluritamig (AMG 509) is a six-transmembrane epithelial antigen of the prostate 1 (STEAP1)-targeted T-cell engager designed to facilitate lysis of STEAP1-expressing cancer …

STEAP1 and STEAP1B gene share high homology and are differentially expressed in human prostate cell lines. A detailed in silico analysis allowed to compare the genomic organization of …

The expression of STEAP1 is associated with higher Gleason scores and a worse prognosis in prostate cancer patients. STEAP1 is only minimally expressed in normal tissues, including the …

• STEAP1 is a membrane protein that is overexpressed in > 80% of prostate cancers, representing an attractive target for treating mCRPC 11-13 • Several modalities are being …

STEAP1, in particular, is highly expressed on the plasma membrane of prostate cancer cells and has received significant attention as a potential therapeutic target. This review highlights what …

STEAP1 gene is overexpressed in several kinds of tumors, particularly in prostate cancer. Besides STEAP1, there is another related gene, STEAP1B, which may encode two different …

2025年1月4日 · STEAP1 facilitates metastasis and epithelial-mesenchymal transition of lung adenocarcinoma via the JAK2/STAT3 signaling pathway. Cryo-electron microscopy structure …

2024年1月12日 · Xaluritamig (AMG 509) is a six-transmembrane epithelial antigen of the prostate 1 (STEAP1)–targeted T-cell engager designed to facilitate lysis of STEAP1-expressing cancer …