The most common is the “star” (*) system, which was implemented in the 1990s and has been widely adopted in the field. In most cases, *1 denotes the default reference (wild type or fully functional) allele or haplotype, while other designations (e.g. *2 or *3) define haplotypes carrying one or more variants .

Star alleles are haplotype patterns at the gene level and are usually associated with protein activity levels, genetic variants of which include single nucleotide polymorphisms (SNPs), Insertion/Deletion (InDels), and copy number variants (CNVs).

2016年4月5日 · The star allele nomenclature is thought to be faster and easier for non-specialized professionals in identifying important pharmacogenetic alleles, helping them avoid transcription mistakes which may be more frequent by using the standard HGVS nomenclature.

2021年2月20日 · Most commonly, reports provide the genotypic results using star (*) nomenclature as an abbreviation for known alleles (different versions of a gene) containing different genomic variants. Some reports will also provide detailed information about the specific DNA variants present.

In pharmacogenetics, star alleles are fundamental predictors of drug response phenotypes. Determining the star alleles an individual carries for a particular gene enables healthcare professionals to personalize treatment protocols based …

What is a star allele? Many pharmacogenes utilize the star allele nomenclature system. This system assigns each haplotype a unique label that comprises the name of the gene followed by the major star (*) allele assignment and subvariant assignments.

2020年8月3日 · Accurately detecting functional haplotypes, popularly known as star (*) alleles, in clinically actionable pharmacogenes (e.g. cytochrome P450 genes) is therefore crucial to the implementation of...

The star-allele system not only provides names for genetic variations, but also plays a crucial role in predicting the functional effects of genetic differences in pharmacogenes.

The star-allele nomenclature is the result of efforts to standardize genetic polymorphism annotation for the cytochrome P450 genes. As clinical pharmacogenetic testing becomes widespread, it is important that this system effectively communicate a patient's genotype and predicted clinical phenotype. …

Star Allele Search is a dynamic query of *alleles (i.e., pharmacogenetic annotations) based on whole genome sequencing data collected from the 1000 Genomes Project sample collection, including 3202 individuals living around the world.