Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in …

XY complete gonadal dysgenesis, also known as Swyer syndrome, is a type of defect hypogonadism in a person whose karyotype is 46,XY. Though they typically have normal vulvas, [1] the person has underdeveloped gonads, fibrous tissue termed "streak gonads", and if left untreated, will not experience puberty.

The SRY gene provides instructions for making a protein called the sex-determining region Y protein. This protein is involved in male-typical sex development, which usually follows a certain pattern based on an individual's chromosomes.

“sry”是什么意思？ 人类决定性别的基因，集中于第23对染色体上，也就是我们所说的性染色体，男性的是XY染色体，而女性的则是XX染色体，男性与女性最大的差别，就在于性染色体的不同，由此产生了性别的分化，男性Y染

SRY (which stands for sex-determining region Y gene) is found on the Y chromosome. In the cell, it binds to other DNA and in doing so distorts it dramatically out of shape. This alters the properties of the DNA and likely alters the expression of a …

英语里，根据情节不同，回复Sorry的情况大致分三种： No.1 完全不用放在心上，可以说：1. That's all right.（没关系） 2. Never mind.（不用担心） 3. No problem.（没事） 4. No worries.（不要多虑） 5. It…

The SRY gene is key in sex determination and development, yet there might be other important genes involved. Two SRY mutations and a polymorphism were identified in two patients with 46,XY complete pure gonadal dysgenesis, demonstrating the importance of the carboxy-terminal region of SRY in DNA binding activity.

2025年3月1日 · SRY contains a highly conserved high mobility group (HMG) box essential for DNA binding and activity. Variants in SRY cause Differences of Sex Development (DSD), accounting for 10–15% of 46, XY gonadal dysgenesis cases. Here, we present the functional analysis of five SRY coding variants identified in patients with 46, XY DSD. Four variants ...

2023年12月20日 · The SRY gene encodes a protein called the SRY protein, which interacts with other molecules in the cell to regulate gene expression and promote the development of male-specific structures. The SRY protein acts as a transcription factor, binding to specific DNA sequences and controlling the expression of genes involved in male sexual development.

2003年10月30日 · SRY, the gene that encodes the sex-determining region Y protein, is the principal gene known to be associated with 46,XX testicular DSD. Approximately 80% of individuals with nonsyndromic 46,XX testicular DSD are SRY positive, as shown by use of FISH or chromosomal microarray.