Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/ transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals (placentals and marsupials). [5] .

The SRY gene provides instructions for making a protein called the sex-determining region Y protein. This protein is involved in male-typical sex development, which usually follows a certain pattern based on an individual's chromosomes. People usually have 46 …

SRY (which stands for sex-determining region Y gene) is found on the Y chromosome. In the cell, it binds to other DNA and in doing so distorts it dramatically out of shape. This alters the properties of the DNA and likely alters the expression of a …

2023年12月20日 · Located on the Y chromosome, the SRY gene is primarily expressed in the cells of the developing gonads. Its expression triggers a cascade of molecular events that lead to the development of testes instead of ovaries. This gene acts as the master regulator of male sexual development.

2024年12月25日 · SRY (Sex Determining Region Y) is a Protein Coding gene. Diseases associated with SRY include 46,Xx Sex Reversal 1 and 46,Xy Sex Reversal 1. Among its related pathways are Mammalian disorder of sexual development and Signaling by WNT.

2013年12月31日 · The Sex-determining Region Y (Sry in mammals but SRY in humans) is a gene found on Y chromosomes that leads to the development of male phenotypes, such as testes. The Sry gene, located on the short branch of the Y chromosome, initiates male embryonic development in the XY sex determination system.

The SRY gene is defined as the critical Y-linked gene responsible for testis determination in mammals. It encodes a protein that plays a key role in inducing the differentiation of pre-Sertoli cells, leading to the formation of testicular cords and male sex development.

2025年2月8日 · Title: SRY gene isolation from teeth for forensic gender identification-An observational study. An extremely rare missense mutation of the androgen receptor gene in a Vietnamese family with complete androgen insensitivity syndrome.

The SRY gene provides instructions for making a protein called the sex-determining region Y protein. This protein is involved in male-typical sex development, which usually follows a certain pattern based on an individual's chromosomes. People usually have 46 …

The gene SRY (sex determining region of the Y), located at the distal region of the short arm of the Y chromosome, is necessary for male sex determination in mammals. SRY initiates the cascade of steps necessary to form a testis from an undifferentiated gonad.