2024年12月25日 · SPRY1 (Sprouty RTK Signaling Antagonist 1) is a Protein Coding gene. Diseases associated with SPRY1 include Renal Hypodysplasia/Aplasia 1 and Legius …

2023年10月12日 · Here, we perform single-cell RNA-sequencing of tumors from patients with ESCC undergoing neoadjuvant ICB, revealing a subset of exhausted CD8 + T cells expressing …

2025年2月9日 · Spry1 plays a selective role in at least a subset of triple-negative breast cancer to promote the malignant phenotype via enhancing EGF-mediated mesenchymal phenotype. …

2023年4月4日 · Mechanistically, SPRY1 interacted with ubiquitin carboxy-terminal hydrolase L1 to induce activation of nuclear factor κB signaling and ultimately increase CXCL12 expression. …

SPRY1 could facilitate cell proliferation and cell cycle progression, and suppress cell apoptosis via activating the Hedgehog pathway in AML.

Sprouty proteins are established modifiers of receptor tyrosine kinase (RTK) signaling and play important roles in vasculogenesis, bone morphogenesis, and renal uteric branching. Little is …

2024年4月26日 · Genes of the Sprouty family (Spry1-4) are feedback inhibitors of receptor tyrosine kinase (RTK) signaling conserved from flies to humans [1]. In mice, Spry genes …

2018年7月23日 · SPRY 1 was mainly located in the cytoplasm of the epidermal keratinocytes from the granular epidermal layer of the skin and cultured cells. Overexpressed SPRY 1 in …

Spry1, a regulator of receptor tyrosine kinases (RTK), plays a role in maintaining the contractile phenotype of VSMC. The aim of the current study was to determine the role of Spry1 in VSMC …

Spry1 -/- embryos had supernumerary uretic buds, resulting in the development of multiple ureters and multiplex kidneys. The defects were due to increased sensitivity of the wolffian duct to …