2024年12月25日 · SPHK1 (Sphingosine Kinase 1) is a Protein Coding gene. Diseases associated with SPHK1 include Renal Fibrosis and Glioblastoma. Among its related pathways are Chaperonin-mediated protein folding and Antiviral mechanism by IFN-stimulated genes.

2020年3月17日 · The sphingosine kinase 1 (SPHK1)/sphingosine-1-phosphate (S1P) signaling axis is emerging as a key player in the development of idiopathic pulmonary fibrosis (IPF) and bleomycin (BLM)-induced lung fibrosis in mice. Recent evidence implicates the involvement of the Hippo/Yes-associated protein (YAP) …

2022年9月1日 · We have elucidated an emerging functionality of SPHK1, identified SPHK1-mediated immunosuppression established by transcriptional regulation of PD-L1 in malignant melanoma and demonstrated a...

2024年12月10日 · Title: SphK1 deficiency ameliorates the development of atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway. Interference with sphingosine kinase-1 reduces the hydrogen peroxide-induced oxidative stress damage in melanocytes through four and a half LIM domains 2.

Sphk1 plays an important role in the malignant transformation of breast epithelial cells and modulates breast cancer metastasis through the regulation of Ecadherin expression. SPHK1 is involved in tumor development and progression of cervical cancer

Sphingosine kinase 1 (SPHK1) regulates cell proliferation and survival by converting sphingosine to the signaling mediator sphingosine 1-phosphate (S1P). SPHK1 is widely overexpressed in most cancers, promoting tumor progression and is associated ...

Sphingosine kinase 1 (SK1) sits a critical junction in the metabolic pathway (Figure 1) as it can control the levels of the pro-apoptotic lipids ceramide and sphingosine and the pro-survival lipid S1P.

2024年12月23日 · Pharmacological inhibition of Sphk1 with PF543 attenuates BBB leakage, reduces hematoma volume, and improves neurological outcomes in mice. At the molecular and ultrastructural level, Sphk1...

2025年2月4日 · M2 macrophage infiltration experiments investigated SPHK1’s role in the glioma immune microenvironment. We identified SPHK1 downstream pathways and further elucidated their regulatory...

Sphingosine kinase 1 (Sphk1) is a highly conserved lipid kinase that functions to phosphorylate sphingosine to form sphingosine-1-phosphate (S1P). The Sphk1/S1P-signaling pathway has exerted important physiological and pathophysiological functions.