2024年12月25日 · SPARCL1 (SPARC Like 1) is a Protein Coding gene. Diseases associated with SPARCL1 include Stromal Corneal Dystrophy and Amelogenesis Imperfecta, Type Ie. Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Metabolism of proteins.

SPARC-like protein 1 (SPARCL1 or SC1), also known as hevin (short for high endothelial venule protein), is a secreted protein with high structural similarity to SPARC. [5] [6] It interacts with the extracellular matrix to create intermediate states of cell adhesion. [7]

2024年5月18日 · Endothelial overexpression of SPARCL1 promotes detrimental lung inflammation, with SPARCL1 inducing ‘M1-like’ macrophages and related pro-inflammatory cytokines, while SPARCL1 deletion...

2019年11月7日 · In this study, bone morphogenetic protein 7 (BMP7) was found to combine with SPARCL1 during the differentiation of C2C12 cells. BMP7, a member of the transforming growth factor (TGF)-β...

富含半胱氨酸的酸性分泌蛋白类似蛋白1 (SPARCL1)基因的异常表达与多种肿瘤的发展、转移及预后密切相关。 近年来研究表明，SPARCL1基因在脑胶质瘤中表达升高，其编码的蛋白可以和胶原相互作用，从而影响肿瘤的转移能力，与肿瘤恶性程度呈正相关。 SPARCL1基因在胃癌、结直肠癌、前列腺癌及乳腺癌等肿瘤组织中低表达，与肿瘤的侵袭及转移能力呈负相关。 目前对于SPARCL1基因发挥作用的具体分子机制仍存在争议，其在肿瘤组织中的表达和功能似乎依赖 …

SPARCL1 (also known as Hevin), a secreted non-neuronal protein, was reported to increase synaptogenesis by simultaneously binding to presynaptic neurexin-1α and to postsynaptic neuroligin-1B, thereby catalyzing formation of trans-synaptic neurexin/neuroligin complexes.

SPARCL1 performs specific functions, including cell adhesion, cell proliferation, and development of the central nervous system by interacting with specific molecules in different ECM environments [2–4].

In order to validate this hypothesis, we focused on SPARCL1, which was the most strongly upregulated gene in Th1-TME–derived TECs. SPARCL1 is a member of the SPARC family of secreted matricellular proteins, together with SPARC/osteonectin, SMOCs, testicans, and follistatin-like protein 1 .

2021年8月19日 · Our findings inaugurate SPARCL1 as a blood vessel-derived anti-angiogenic molecule required for vessel morphogenesis and integrity. SPARCL1 opens new perspectives as a vascular marker of susceptibility to colitis and as a therapeutic molecule to support blood vessel stability in this disease.

Predicted to enable calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Predicted to be involved in anatomical structure development and regulation of synapse organization. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]