SOX17 is involved in the regulation of vertebrate embryonic development and in the determination of the endodermal cell fate. The encoded protein acts downstream of TGF beta signaling (Activin) and canonical WNT signaling (Wnt3a).

2024年12月25日 · SOX17 (SRY-Box Transcription Factor 17) is a Protein Coding gene. Diseases associated with SOX17 include Vesicoureteral Reflux 3 and Familial Vesicoureteral Reflux. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Signaling by WNT.

2024年2月28日 · We propose that SOX17 is a transcription factor that is engaged during the early steps of colon cancer to orchestrate an immune-evasive programme that permits CRC initiation and progression.

2025年2月8日 · SOX17 might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC. Decreased Sox17 expression is correlated with melanoma progression, an unfavorable survival of melanoma patients and …

2013年10月24日 · Here we report that the transcription factor Sox17, which is known as a regulator of endoderm and hemopoietic differentiation, is selectively expressed in arteries, and not in veins, in the...

2024年2月28日 · Precancerous colon cells can avoid immune detection by turning on a gene called SOX17, which allows them to become essentially invisible to the immune system, an MIT study finds.

2015年1月15日 · Different from that in mice, SOX17 is the key regulator for human primordial germ cell specification, suggesting fundamental differences between early mouse and human development.

2024年12月10日 · Title: SOX17 is a Critical Factor in Maintaining Endothelial Function in Pulmonary Hypertension by an Exosome-Mediated Autocrine Manner. Dysregulation of SOX17/NRF2 axis confers chemoradiotherapy resistance and emerges as a novel therapeutic target in esophageal squamous cell carcinoma.

2011年3月4日 · By using homologous recombination in human ESCs, we inserted an enhanced green fluorescent protein (eGFP) transgene into the SOX17 locus, a postulated marker of human endoderm.

Here we identify Sox17 as a key regulator of HE development. Analysis of Sox17 -GFP reporter mice revealed that Sox17 is expressed in HE and emerging HSCs and that it is required for HSC development.