2024年12月25日 · SOCS5 (Suppressor Of Cytokine Signaling 5) is a Protein Coding gene. Diseases associated with SOCS5 include Spinal Cord Sarcoma and Conjunctivitis. Among its related pathways are Metabolism of proteins and Cytokine Signaling in Immune system.

Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene. [5] [6] [7] The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family.

Seki and colleagues suggest SOCS5 interacts via its N-terminus with the IL-4 receptor alpha (IL-4Rα) Box 1 region, blocking JAK1 association and subsequent Th2 differentiation. Indeed, expression of a T cell-specific SOCS5 transgene augments the Th1 response in mouse models of bacterial sepsis and allergic conjunctivitis [69, 102, 103].

2019年8月13日 · Our study aims to unravel novel functions of SOCS5 in HCC, especially that affecting metastasis. We examined the expression levels of SOCS5 in HCC using publicly available datasets, and in our...

SOCS5 contributes to temozolomide resistance in glioblastoma by regulating Bcl-2-mediated autophagy. Inhibition of microRNA-448 suppresses CD4(+) T cell inflammatory activation via up-regulating suppressor of cytokine signaling 5 in systemic lupus erythematosus.

Socs5 −/− mice were born in a normal Mendelian ratio and were healthy and fertile. We found that SOCS5 is expressed in primary B and T cells in wild-type mice. However, no abnormalities in the lymphocyte compartment were seen in SOCS5-deficient mice.

2007年5月18日 · Suppressor of cytokine signalling (SOCS) proteins are inhibitors of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathways. SOCS1 also inhibits Toll-like...

2019年8月13日 · SOCS5 is a member of the suppressor of cytokine signaling (SOCS) protein family with important yet incompletely understood biological functions in cancer. In hepatocellular carcinoma (HCC), controversial tumor-promoting and tumor-suppressive roles of …

Mechanistically, SOCS5 silencing induces activation of JAK-STAT signaling, and negatively regulates interleukin-7 and interleukin-4 receptors. Using a human T-ALL murine xenograft model, we show that genetic inactivation of SOCS5 accelerates leukemia engraftment and progression, and leukemia burden.

2024年3月5日 · SOCS5 contributes to temozolomide resistance in glioblastoma by regulating Bcl-2-mediated autophagy. SOCS5 inhibition induces autophagy to impair metastasis in hepatocellular carcinoma cells via the PI3K/Akt/mTOR pathway. Zhang M, Liu S, Chua MS, Li H, Luo D, Wang S, Zhang S, Han B, Sun CZhang M, et al. Cell Death Dis, 2019 Aug 13. PMID …