2024年12月25日 · SOCS5 (Suppressor Of Cytokine Signaling 5) is a Protein Coding gene. Diseases associated with SOCS5 include Spinal Cord Sarcoma and Conjunctivitis. Among its …

Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene. [5] [6] [7] The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. …

Seki and colleagues suggest SOCS5 interacts via its N-terminus with the IL-4 receptor alpha (IL-4Rα) Box 1 region, blocking JAK1 association and subsequent Th2 differentiation. Indeed, …

2019年8月13日 · Our study aims to unravel novel functions of SOCS5 in HCC, especially that affecting metastasis. We examined the expression levels of SOCS5 in HCC using publicly …

SOCS5 contributes to temozolomide resistance in glioblastoma by regulating Bcl-2-mediated autophagy. Inhibition of microRNA-448 suppresses CD4(+) T cell inflammatory activation via …

Socs5 −/− mice were born in a normal Mendelian ratio and were healthy and fertile. We found that SOCS5 is expressed in primary B and T cells in wild-type mice. However, no abnormalities in …

2007年5月18日 · Suppressor of cytokine signalling (SOCS) proteins are inhibitors of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathways. SOCS1 also …

2019年8月13日 · SOCS5 is a member of the suppressor of cytokine signaling (SOCS) protein family with important yet incompletely understood biological functions in cancer. In …

Mechanistically, SOCS5 silencing induces activation of JAK-STAT signaling, and negatively regulates interleukin-7 and interleukin-4 receptors. Using a human T-ALL murine xenograft …

2024年3月5日 · SOCS5 contributes to temozolomide resistance in glioblastoma by regulating Bcl-2-mediated autophagy. SOCS5 inhibition induces autophagy to impair metastasis in …