SOAT1 - Wikipedia
SOAT1 is a polytopic integral membrane protein belonging to the membrane-bound O-acyltransferase (MBOAT) superfamily. The structure of SOAT1 has not yet been solved but …
SOAT1 Gene - GeneCards | SOAT1 Protein | SOAT1 Antibody
2024年12月25日 · SOAT1 (Sterol O-Acyltransferase 1) is a Protein Coding gene. Diseases associated with SOAT1 include Niemann-Pick Disease, Type C1 and Chronic Leukemia. …
SOAT1 regulates cholesterol metabolism to induce EMT in
2024年5月9日 · Here we demonstrated that SOAT1 positively related to poor prognosis of HCC, EMT markers and promoted cell migration and invasion in vitro, which was mediated by the …
SOAT1 deficiency attenuates atherosclerosis by regulating inflammation ...
2018年6月22日 · Sterol O-acyltransferase 1 (SOAT1) is a key enzyme for cholesteryl ester biosynthesis. The objective of the present study is to investigate the role and underlying …
SOAT1 sterol O-acyltransferase 1 [ (human)] - National Center for ...
High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer. …
Structural insights into the inhibition mechanism of human sterol
Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) …
Targeting sterol-O-acyltransferase 1 to disrupt cholesterol …
In this review, we mainly discuss the cholesterol metabolism centered on SOAT1 and mechanisms that regulate SOAT1 expression in cancers. Finally, the latest developments that …
SOAT1 promotes mevalonate pathway dependency in pancreatic …
2020年9月7日 · We identified sterol O-acyltransferase 1 (SOAT1) as a key player in sustaining the mevalonate pathway by converting cholesterol to inert cholesterol esters, thereby …
Simultaneously targeting SOAT1 and CPT1A ameliorates ... - Nature
2021年5月29日 · Here, we found high-fat diet (HFD) improved the expression of sterol o-acyltransferase1 (SOAT1) and carnitine palmitoyltransferase 1A (CPT1A) in diethylnitrosamine …
Structural insights into the inhibition mechanism of human sterol …
2020年5月18日 · Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase …