Dec 25, 2024 · SMAD3 (SMAD Family Member 3) is a Protein Coding gene. Diseases associated with SMAD3 include Loeys-Dietz Syndrome 3 and Aortic Aneurysm. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and …

The SMAD3 gene provides instructions for making a protein involved in transmitting chemical signals from the cell surface to the nucleus. Learn about this gene and related health conditions.

Feb 24, 2016 · Here, we show that Smad3 is an insensitive TGFβ transducer as compared with Smad2. Smad3 preferentially localizes within the nucleus and is thus sequestered from membrane signaling. The ability...

Signaling of transforming growth factor β (TGF-β) is mediated through a heteromeric complex of two types of transmembrane receptors and downstream intracellular proteins known as Smads. Alterations of TGF-β signaling underlie various forms of …

SMAD3 knockdown significantly inhibits lung adenocarcinoma cell growth and increases radiosensitivity via P21. This suggests that SMAD3 is a potential prognostic and radiosensitivity indicator and a target for radiotherapy and other treatments for lung adenocarcinoma patients .

Smad3, the best-characterized member of the family plays a critical role in activation of a myofibroblast phenotype, stimulation of ECM synthesis, integrin expression and secretion of proteases and anti-proteases.

SMAD3 regulates transcription of MuRF-1 by increasing FoxO3 binding at a conserved FRE-SBE motif within the proximal promoter region, and by increasing FoxO3 protein content and transcriptional activity. SMAD3 was identified as a target of miR-145 in cystic fibrosis patients.

2 days ago · SMAD3 cooperates with FOXO3 to mediate cell cycle arrest by upregulating p21. Studies in Molecular Cell (2021) show that FOXO3 enhances SMAD3 occupancy at genomic loci, reinforcing TGF-β’s growth-inhibitory effects. Conversely, interactions with c-MYC can antagonize SMAD3, disrupting tumor suppression and promoting oncogenic gene expression.

Jan 3, 2025 · SMAD3, a protein-coding gene, assumes a pivotal role within the transforming growth factor-beta (TGF-β) signaling pathway. Notably, aberrant SMAD3 expression has been linked to various...

Jan 4, 2025 · Smad3 and Smad3 phosphoisoforms are prognostic markers of gastric carcinoma. Phospho-Smad3L promotes progression of hepatocellular carcinoma through decreasing miR-140-5p level and stimulating epithelial-mesenchymal transition. Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer.