Dec 25, 2024 · SLC7A8 (Solute Carrier Family 7 Member 8) is a Protein Coding gene. Diseases associated with SLC7A8 include Lysinuric Protein Intolerance and Hartnup Disorder. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Response to elevated platelet cytosolic Ca2+.

Nov 16, 2022 · These findings identify Slc7a8 as a key supplier of amino acids for the metabolic programs underpinning fitness and activation of ILC2s. Keywords: allergy; amino acid; asthma; innate lymphoid cells; transporter.

Here, we show that SLC7A8 is the key amino acid transporter in ILC2s. Slc7a8 deletion in lymphocytes reduced ILC2s and attenuated responses to helminth infection and house dust mite allergens. Slc7a8 deficiency compromised mitochondrial OXPHOS and mammalian target of rapamycin and c-Myc pathways in ILC2s.

Feb 8, 2025 · The solute carrier SLC7A8 is a marker of favourable prognosis in ER-positive low proliferative invasive breast cancer. These preliminary data suggest that a relevant proportion of age-related hearing loss cases could be explained by SLC7A8 mutations.

Jan 18, 2024 · The downregulation of SLC7A8 was related to a dismal prognosis and immune cell infiltration in LUAD. Increasing the expression of <i>SLC7A8</i> inhibited the growth and migration of LUAD cells, thereby improving the prognosis of patients.

Here, we report findings from targeting a novel potential human adipogenic gene (SLC7A8) under conditions of obesity development using a mouse model of diet-induced obesity (DIO). The results indicate that deleting slc7a8 in mice significantly protects …

Feb 16, 2022 · This study demonstrates that targeting slc7a8 protects against diet-induced obesity by reducing lipid accumulation in multiple organs and suggests that if targeted, has the potential to mitigate the development of obesity-associated comorbidities.

Feb 8, 2025 · Gene ID: 50934, updated on 8-Feb-2025. Enables glycine transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Involved in carboxylic acid transport and thyroid hormone transport. Acts upstream of or within L-amino acid transport. Located in apical plasma membrane.

Apr 27, 2010 · Using the opossum cDNAs to search a sequence database, they identified human ESTs encoding SLC7A8, which they named LAT2. The deduced 535-amino acid SLC7A8 protein has 12 predicted transmembrane domains, with the N and C termini intracytoplasmic. It contains a cysteine residue that is conserved in human 4F2 light chains.

Dec 10, 2024 · Title: The solute carrier SLC7A8 is a marker of favourable prognosis in ER-positive low proliferative invasive breast cancer. These preliminary data suggest that a relevant proportion of age-related hearing loss cases could be explained by SLC7A8 mutations.