2024年12月25日 · SLC7A5 (Solute Carrier Family 7 Member 5) is a Protein Coding gene. Diseases associated with SLC7A5 include Respiratory System Cancer and Lysinuric Protein Intolerance. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Blood-Brain Barrier: Anatomy.

2021年1月7日 · We show that concomitant mutation of Apc and Kras in the mouse intestinal epithelium profoundly rewires metabolism, increasing glutamine consumption. Furthermore, SLC7A5, a glutamine antiporter,...

Here, we show that the amino acid transporter Slc7a5 / Lat1 is highly expressed in tissues undergoing morphogenesis and that Slc7a5 ‐null mouse embryos have profound neural and limb bud outgrowth defects.

2018年6月22日 · SLC7A5, known as LAT1, belongs to the APC superfamily and forms a heterodimeric amino acid transporter interacting with the glycoprotein CD98 (SLC3A2) through a conserved disulfide. The complex is responsible for uptake of essential amino acids in crucial body districts such as placenta and blood br …

We show that concomitant mutation of Apc and Kras in the mouse intestinal epithelium profoundly rewires metabolism, increasing glutamine consumption. Furthermore, SLC7A5, a glutamine antiporter, is critical for colorectal tumorigenesis in models of both early- …

2020年11月4日 · Pathogenic mutations in the solute carrier family 7 member 5 (SLC7A5) gene, which encodes an amino acid transporter cause microcephaly and seizures, yet the mechanisms responsible for these phenotypes are unclear.

SLC7A5 is an antiporter that can export glutamine, 40 and intracellular glutamine levels were increased in SLC7A5 KO cell lines in arginine-free media (Figures S2D and S2E). We next quantified the effects of SLC7A5 deletion on the total consumption of citrulline in …

Study shows that the solute carrier transporter 7a5 (SLC7A5), a large neutral amino acid transporter localized at the blood brain barrier (BBB), has an essential role in maintaining normal levels of brain branched-chain amino acids; also identified several patients with autistic traits and motor delay carrying deleterious homozygous mutations ...

2022年10月2日 · SLC7A5 mediates large neutral amino acids transportation across plasma membrane in a Na+ independent manner, which supplies essential amino acid for somatic cells [33, 34]. SLC7A5 is not only involved in suppling amino acids to cancer cells but also oncogenic signaling pathways such as mTORC1 signaling pathway . Herein, we found SLC7A5 was ...

The amino acid transporter named solute carrier family 7 member 5 (SLC7A5) is suggested to play a part in altered cell metabolism and proliferative signaling and has been reported to be overexpressed in various types of cancer, including breast cancer.