
SLC7A5 Gene - GeneCards | LAT1 Protein | LAT1 Antibody
2024年12月25日 · SLC7A5 (Solute Carrier Family 7 Member 5) is a Protein Coding gene. Diseases associated with SLC7A5 include Respiratory System Cancer and Lysinuric Protein Intolerance. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Blood-Brain Barrier: Anatomy.
The amino acid transporter SLC7A5 is required for efficient ... - Nature
2021年1月7日 · We show that concomitant mutation of Apc and Kras in the mouse intestinal epithelium profoundly rewires metabolism, increasing glutamine consumption. Furthermore, SLC7A5, a glutamine antiporter,...
Wnt regulates amino acid transporter Slc7a5 and so constrains the ...
Here, we show that the amino acid transporter Slc7a5 / Lat1 is highly expressed in tissues undergoing morphogenesis and that Slc7a5 ‐null mouse embryos have profound neural and limb bud outgrowth defects.
The Human SLC7A5 (LAT1): The Intriguing Histidine/Large
2018年6月22日 · SLC7A5, known as LAT1, belongs to the APC superfamily and forms a heterodimeric amino acid transporter interacting with the glycoprotein CD98 (SLC3A2) through a conserved disulfide. The complex is responsible for uptake of essential amino acids in crucial body districts such as placenta and blood br …
The amino acid transporter SLC7A5 is required for efficient ... - PubMed
We show that concomitant mutation of Apc and Kras in the mouse intestinal epithelium profoundly rewires metabolism, increasing glutamine consumption. Furthermore, SLC7A5, a glutamine antiporter, is critical for colorectal tumorigenesis in models of both early- …
The amino acid transporter Slc7a5 regulates the mTOR …
2020年11月4日 · Pathogenic mutations in the solute carrier family 7 member 5 (SLC7A5) gene, which encodes an amino acid transporter cause microcephaly and seizures, yet the mechanisms responsible for these phenotypes are unclear.
SLC7A5 is required for cancer cell growth under arginine-limited ...
SLC7A5 is an antiporter that can export glutamine, 40 and intracellular glutamine levels were increased in SLC7A5 KO cell lines in arginine-free media (Figures S2D and S2E). We next quantified the effects of SLC7A5 deletion on the total consumption of citrulline in …
SLC7A5 solute carrier family 7 member 5 [ (human)]
Study shows that the solute carrier transporter 7a5 (SLC7A5), a large neutral amino acid transporter localized at the blood brain barrier (BBB), has an essential role in maintaining normal levels of brain branched-chain amino acids; also identified several patients with autistic traits and motor delay carrying deleterious homozygous mutations ...
SLC7A5 is a lung adenocarcinoma-specific prognostic biomarker …
2022年10月2日 · SLC7A5 mediates large neutral amino acids transportation across plasma membrane in a Na+ independent manner, which supplies essential amino acid for somatic cells [33, 34]. SLC7A5 is not only involved in suppling amino acids to cancer cells but also oncogenic signaling pathways such as mTORC1 signaling pathway . Herein, we found SLC7A5 was ...
SLC7A5 is linked to increased expression of genes related to ...
The amino acid transporter named solute carrier family 7 member 5 (SLC7A5) is suggested to play a part in altered cell metabolism and proliferative signaling and has been reported to be overexpressed in various types of cancer, including breast cancer.
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