4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene. [5][6] SLC3A2 comprises the heavy subunit of the large neutral amino acid transporter (LAT1) that is also known …

2024年12月25日 · SLC3A2 (Solute Carrier Family 3 Member 2) is a Protein Coding gene. Diseases associated with SLC3A2 include Lysinuric Protein Intolerance and Hepatitis C Virus. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Proximal tubule transport.

SLC3A2 inhibits ferroptosis in laryngeal carcinoma via mTOR pathway. The heavy chain of 4F2 antigen promote prostate cancer progression via SKP-2. Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells.

SLC3A2 (CD98hc) is a tumor-associated antigen that is highly expressed in a variety of hematological and solid tumors, and due to its important role in tumorigenesis, progression, and metastasis, SLC3A2 transmembrane proteins are currently being considered as potential targets for the development of new cancer drugs [197].

2019年10月1日 · On the basis of our findings, we conclude that CD98hc plays a central role in AA and glucose cellular nutrition, redox homeostasis and nucleotide availability, all key for cell proliferation....

2018年12月28日 · In the present study, we characterized the role of SLC3A2 during the unfolded protein response (UPR), as one of the primary pathways activated during ER stress. First, we confirmed the induction of Slc3a2 mRNA expression following treatment with various ER stress inducers in rat cardiomyocytes (H9C2) and neural cells (PC12).

2018年1月1日 · SLC3A2 constitutes the ancillary protein of six human amino acid transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10, and SLC7A11; Fotiadis et al. 2013); it also functions as a coreceptor of β-integrins, amplifying their downstream outside-in …

2021年12月28日 · In the present study, we characterized the role of SLC3A2 during the unfolded protein response (UPR), as one of the primary pathways activated during ER stress. First, we confirmed the induction of Slc3a2 mRNA expression following treatment with various ER stress inducers in rat cardiomyocytes (H9C2) and neural cells (PC12).

2004年12月29日 · CD98 heterodimers, comprised of a heavy chain (CD98hc, SLC3A2) and one of several light chains, interact with integrins through CD98hc. CD98hc overexpression leads to anchorage-independent cell growth and tumorigenesis in 3T3 fibroblasts and activates certain integrin-regulated signaling pathways.

In this study, we analyzed SLC3A2 mRNA levels in human lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) using the TCGA database and serum SLC3A2 protein levels using ELISA. We confirmed high SLC3A2 levels in both the …