2024年12月25日 · SLC1A3 (Solute Carrier Family 1 Member 3) is a Protein Coding gene. Diseases associated with SLC1A3 include Episodic Ataxia, Type 6 and Alternating Hemiplegia Of Childhood. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Neurotransmitter uptake and metabolism In glial cells.

The SLC1A3 gene provides instructions for making a protein called excitatory amino acid transporter 1 (EAAT1). The EAAT1 protein is primarily found in nervous system cells called glia (or glial cells), which protect and maintain nerve cells (neurons).

However, many clinical trials indicated severe ASNase toxicity in patients with solid tumors, with resistant mechanisms not well understood. Here, we took a functional genetic approach and identified SLC1A3 as a novel contributor to ASNase resistance in cancer cells.

within SLC1A3 is associated with accelerated epileptogenesis and clinical post-traumatic seizure development after severe traumatic brain injury; SLC1A3 expression promoted tumor development and metastasis while negating the suppressive effects of ASNase by fueling aspartate, glutamate, and glutamine metabolisms despite of asparagine shortage

2024年11月19日 · Elevated levels of SLC1A3 promote HCC cell motility and invasion and can affect the prognosis of HCC by modifying immune responses and epithelial-mesenchymal transition. SLC1A3 has emerged as a novel prognostic marker in HCC and is associated with resistance to certain antitumor drugs.

2018年4月2日 · EAAT1 (SLC1A3) is a member of a family of high-affinity sodium-dependent transporter molecules that regulate neurotransmitter concentrations at the excitatory glutamatergic synapses of the mammalian central nervous system (Kirschner et al., 1994).

SLC1A3 functions as a cancer-promoting factor contributing to poor HCC prognosis by affecting immune cell infiltration and regulating the EMT process. Elevated SLC1A3 expression may also serve as a predictor of treatment response to specific antitumor drugs. Keywords: Hepatocellular carcinoma, SLC1A3, Immune infiltration, EMT, Prognosis ...

2018年11月6日 · We show here that p53 promotes the expression of SLC1A3, an aspartate/glutamate transporter that allows the utilization of aspartate to support cells in the absence of extracellular glutamine.

2024年12月25日 · SLC1A1 (Solute Carrier Family 1 Member 1) is a Protein Coding gene. Diseases associated with SLC1A1 include Dicarboxylic Aminoaciduria and Schizophrenia 18. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Proximal tubule transport.

SLC1A2 and SLC1A3 are Na +-dependent glutamate transporters mainly expressed in astrocytes and function in modulating glutamatergic activity in the brain.