SLC1A2 Gene - GeneCards | EAA2 Protein | EAA2 Antibody
2024年12月25日 · SLC1A2 (Solute Carrier Family 1 Member 2) is a Protein Coding gene. Diseases associated with SLC1A2 include Developmental And Epileptic Encephalopathy 41 and Non-Specific Early-Onset Epileptic Encephalopathy .
清华大学药学院陈立功课题组应邀发表多篇综述文章阐述转运蛋白 …
谷氨酸转运蛋白 slc1a1、slc1a2 和 slc1a3主要在大脑中表达，它们有助于防止谷氨酸兴奋性毒性，对多发性硬化症等中枢神经系统 (cns) 疾病有重要的作用（图3）。
Excitatory amino acid transporter 2 - Wikipedia
Excitatory amino acid transporter 2 (EAAT2) also known as solute carrier family 1 member 2 (SLC1A2) and glutamate transporter 1 (GLT-1) is a protein that in humans is encoded by the SLC1A2 gene. [5] [6] Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [6]
溶质载体家族 1 成员 2（SLC1A2）基因 | MCE
关于 slc1a2 Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:35,251,205-35,420,507 (from NCBI) This gene has 50 transcripts (splice variants), 287 orthologues, 6 paralogues and is associated with 3 phenotypes.
SLC1A2 solute carrier family 1 member 2 [ (human)]
SLC1A2 variant is associated with elevated anterior cingulate cortex glutamate and lifetime history of rapid cycling in mood disorders. The Na(+)/Ca(2+) exchanger (NCX) plays a dominant role in this Ca(2+) mobilization and its blockade suppresses the …
Recurrent SLC1A2 variants cause epilepsy via a dominant …
SLC1A2 is a trimeric transporter essential for clearing glutamate from neuronal synapses. Recurrent de novo SLC1A2 missense variants cause a severe, early onset developmental and epileptic encephalopathy via an unclear mechanism. We demonstrate that all 3 variants implicated in this condition locali …
The GLT-1 (EAAT2; slc1a2) glutamate transporter is essential for ...
The GLT-1 (EAAT2; slc1a2) glutamate transporter is essential for glutamate homeostasis in the neocortex of the mouse J Neurochem . 2014 Mar;128(5):641-9. doi: 10.1111/jnc.12509.
Functional investigation of SLC1A2 variants associated with epilepsy
2022年12月21日 · In the present study, we confirmed that the clinically reported epileptic SLC1A2 variants (G82R, L85P, and P289R) decreased the expression and function of GLT-1, and inhibit glutamate-elicited ...
NF-κB通过Slc1a2调控树突状细胞成熟及功能的研究
本研究发现，NF-κB抑制剂TPCK预处理能够抑制LPS诱导的DC成熟及Slc1a2表达，并且混合淋巴细胞反应结果显示DC胞内Slc1a2的表达水平直接影响了Th17的分化，推测通过NF-κB信号通路能够调控DC胞内Slc1a2的表达，进而决定Th17的分化。
SLC1A2- 信号通路|蛋白抗体-华美生物
slc1a2，即溶质载体家族1成员2，别名eaat2、glt-1等。 它是一种由SLC1A2基因编码的跨膜蛋白，主要在大脑神经元和胶质细胞中表达。 SLC1A2的作用机制涉及介导细胞外谷氨酸的转运，将其带入细胞内，对维持中枢神经系统的谷氨酸稳态至关重要。