Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL
2019年11月26日 · Timed degradation of the cyclin-dependent kinase inhibitor p27 Kip1 by the E3 ubiquitin ligase F-box protein SKP2 is critical for T-cell progression into cell cycle, coordinating …
Skp2 Inhibitors: Novel Anticancer Strategies - PubMed
Taken together, inhibition of Skp2 functions (either proteolytic function or non-proteolytic function) is emerging as a promising and novel anti-cancer strategy. In the present review, we highlight …
The Skp2 Pathway: A Critical Target for Cancer Therapy - PMC
These observations highlight the unexpected anti-neoplasm function of Troglitazone through targeting Skp2. Of note, using a high throughput platform, a total of 7368 chemical compounds …
Dioscin: A new potential inhibitor of Skp2 for cancer therapy
In the current issue of EBioMedicine, Zhou et al. validated a new Skp2 inhibitor, dioscin, which is obtained from a natural steroid saponin, for potential use in colorectal cancer (CRC) treatment …
The Skp2 Pathway: A Critical Target for Cancer Therapy
To that end, the oncogenic properties of Skp2 are demonstrated by various genetic mouse models, highlighting the potential of Skp2 as a target for tackling cancer. In this article, we will …
Targeted inhibition of SCF SKP2 confers anti-tumor activities
2024年2月14日 · The synergistic effect that we found when targeting Skp2 together with conventional chemotherapy indicate SKP2 inhibitors re-sensitize chemo-resistant tumors for …
Dioscin: A new potential inhibitor of Skp2 for cancer therapy
2020年1月2日 · In the current issue of EBioMedicine, Zhou et al. validated a new Skp2 inhibitor, dioscin, which is obtained from a natural steroid saponin, for potential use in colorectal cancer …
Skp2: A dream target in the coming age of cancer therapy
The current study identifies a specific Skp2 inhibitor compound #25 that phenocopies the effect of Skp2 deficiency to target tumorigenesis by upregulation of p27 tumor suppressor and …
Small-molecule compounds inhibiting S-phase kinase-associated …
DT204 is an Skp2 inhibitor identified by virtual and computational screening against multiple myeloma RPMI8226 cells. DT204 prevents Skp2 from incorporating into the SCF Skp2 …
Skp2 inhibitor SKPin C1 decreased viability and proliferation of ...
2019年4月25日 · A small molecule inhibitor of Skp2, named SKPin C1, was developed and confirmed to demonstrate an inhibitory effect on cell proliferation in human skin malignant …