NAD-dependent deacetylase sirtuin 7 is an enzyme that in humans is encoded by the SIRT7 gene. [5][6][7] SIRT7 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein. SIRT7 facilitates the transcription of DNA by RNA polymerase I, RNA polymerase II, and RNA polymerase III. [8]

2024年12月25日 · SIRT7 (Sirtuin 7) is a Protein Coding gene. Diseases associated with SIRT7 include Lysosomal Storage Disease and Prostate Cancer. Among its related pathways are NAD metabolism and p53 Signaling. Gene Ontology (GO) annotations related to this gene include chromatin binding and NAD-dependent histone H3K18 deacetylase activity.

As a member of the Sirtuins family in mammals, SIRT7 locates in nucleus and is a highly specific H3K18Ac (acetylated lysine 18 of histone H3) deacetylase. Recent studies showed that SIRT7 could participate in the ribosomal RNA transcription, cell metabolism, cell stress and DNA damage repair through various signaling pathways.

2024年2月21日 · SIRT7 distinguishes itself as the exclusive mammalian Sirtuin primarily localized within the nucleolus, a crucial organelle involved in ribosome biogenesis. In this compartment, SIRT7...

2025年2月4日 · Here, we report structures of nucleosome-bound SIRT7, and uncover the structural basis of its specificity towards H3K36 and K18 deacylation, combining a mechanism-based cross-linking strategy ...

2023年9月19日 · SIRT7通过去乙酰化Fibrillarin和PAF53促进RNA polymerase I介导的rRNA的转录。SIRT7还可以直接去乙酰化U3-55k进而调控U3 snoRNA对18S rRNA的成熟加工过程。

2016年7月20日 · We show that SIRT7 is recruited to DNA double-strand breaks (DSBs) in a PARP1-dependent manner and catalyses desuccinylation of H3K122 therein, thereby promoting chromatin condensation and DSB...

SIRT7, a member of the sirtuin family of NAD +-dependent protein deacetylases, is a key mediator of many cellular activities. SIRT7 expression is linked to cell proliferation and oncogenic activity, connecting SIRT7-dependent regulation of ribosome biogenesis with checkpoints controlling cell cycle progression, metabolic homeostasis, stress ...

sirt7能够支持心脏细胞功能，保护心肌细胞免受氧化应激和炎症损伤，延缓心脏因年龄增长而出现的退化。此外，sirt7还与dna修复相关，可以延长心脏细胞的寿命，帮助维持心血管系统的稳定性。 总结. sirt1至sirt7在抗衰老和健康维护中具有各自独特的作用。

2017年1月1日 · Mammalian SIRT7 is a member of the sirtuin family that regulate multiple biological processes including genome stability, metabolic pathways, stress responses, and tumorigenesis. SIRT7 has been shown to be important for ribosome biogenesis and transcriptional regulation.