2024年12月25日 · SIRPB1 (Signal Regulatory Protein Beta 1) is a Protein Coding gene. Diseases associated with SIRPB1 include Immunodeficiency 50 and Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1 .

Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene. [5] [6] [7] SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B). The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily.

2024年4月9日 · Our study demonstrates that glioma cells can be activated by macrophages via SIRPB1, subsequently reprogramming the TME, suggesting that SIRPB1 could serve as a promising therapeutic target for gliomas.

SIRPB1 gene amplification and overexpression were detected in prostate cancer specimens. The knockdown of SIRPB1 significantly suppressed cell growth in colony formation assays and cell mobility. SIRPB1 knockdown also induced cell cycle arrest during the G 0 /G 1 phase and enhancement of apoptosis.

该基因编码的蛋白质是信号调节蛋白 (SIRP) 家族的一员，也属于免疫球蛋白超家族。 SIRP 家族成员是受体型跨膜糖蛋白，已知参与受体酪氨酸激酶偶联信号传导过程的负调节。 发现该蛋白质与 TYROBP/DAP12 相互作用，TYROBP/DAP12 是一种带有免疫受体酪氨酸激活基序的蛋白质。 据报道，该蛋白质还参与了酪氨酸激酶 Syk 的募集。 已发现该基因编码不同异构体的多个转录变体。 [RefSeq 提供，2009 年 2 月]

Assigned HPA protein class (es) for the encoded protein (s). Number of protein-coding transcripts from the gene as defined by Ensembl. A summary of the overall protein expression profile across the analyzed normal tissues based on knowledge-based annotation, presented in the Tissue resource. "Estimation of protein expression could not be performed.

2024年4月9日 · SIRPB1 activation with certain antibodies results in SYK phosphorylation and the subsequent activation of calcium, MAPK, and NF-κB signaling pathways. This phenomenon is primarily observed in myeloid-derived cells as opposed to glioma cells.

2024年6月19日 · SIRPB1 copy-number polymorphism as candidate quantitative trait locus for impulsive-disinhibited personality. SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration. Liu Y, Soto I, Tong Q, Chin A, Bühring HJ, Wu T, Zen K, Parkos CALiu Y, et al. J Biol Chem, 2005 Oct 28.

2024年3月5日 · SIRPbeta1 is a novel IFN-induced microglial receptor that supports clearance of neural debris and Abeta aggregates by stimulating phagocytosis. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.

通过对信号调节蛋白B1 (SIRPB1)对前列腺癌细胞功能学的研究，探索SIRPB1在前列腺癌中发生发展中的作用以及相关的分子机制。 研究方法： 1.通过对cBioportal数据库分析SIRPB1在前列腺癌的表达 2.... 研究目的： 目前随着中国经济的发展，中国恶性肿瘤发病率逐渐上升，已经成为中国人民的首要死亡原因，严重影响了人们的生存质量和预期寿命，对社会和经济的发展造成沉重的负担。 在美国前列腺癌作为一种最常见的男性恶性肿瘤，其癌症病因死亡率跃居男性恶性肿瘤的 …