Sonic hedgehog signalling pathway: a complex network - PMC
Sonic Hedgehog (Shh) signalling pathway is one of the major trafficking networks that regulates the key events during developmental processes i.e growth and patterning of multicellular embryos. 1 Aberration in the regulation and transduction of the Shh signalling pathway has been implicated in birth defects, tissue regeneration, stem cell ...
Hedgehog 信号通路 - 知乎 - 知乎专栏
2023年7月16日 · Hedgehog信号通路是一个经典得控制胚胎发育得信号途径，在胚胎发育和胚胎形成后细胞得生长、增殖过程中起重要作用。 Hedgehog信号通路得缺失将导致发育缺陷。 Hedgehog信号通路的组成： （1）Hedgehog配体（SHH、DHH、IHH） （2）细胞膜上两种受体 Patched (Ptc)和Smoothened (Smo) 控制。 PTCH1、PTCH2分别编码成Hedgehog信号通路中的负调控蛋白Patched1、Patched2。 SMO编码Hedgehog信号通路中的正调控蛋白Smoothened。
Hedgehog signaling pathway - Wikipedia
The Hedgehog signaling pathway is one of the key regulators of animal development and is present in all bilaterians. [3] The pathway takes its name from its polypeptide ligand, an intracellular signaling molecule called Hedgehog (Hh) found in fruit flies of the genus Drosophila; fruit fly larvae lacking the Hh gene are said to resemble hedgehogs.
A highlight on Sonic hedgehog pathway - Cell Communication and Signaling
2018年3月20日 · Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is important for the evolution of radio and chemo-resistance of several types of tumors.
Hedgehog signaling in tissue homeostasis, cancers and targeted …
2023年8月18日 · HH signaling pathway exerts its biological effects through a complex signaling cascade involved with primary cilium. HH signaling pathway has important functions in embryonic development...
Targeting the Sonic Hedgehog Signaling Pathway: Review of …
The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in a variety of human cancers, including, basal cell carcinoma, malignant gliomas, medulloblastoma, leukemias, and cancers of the breast, lung, pancreas, and ...
The Role of Sonic Hedgehog Pathway in the Development of the …
Here, we summarize the role and mechanism of the SHH signaling pathway in the development of the central nervous system and aging-related neurodegenerative diseases. In this review, we will also highlight the potential of the SHH pathway as a therapeutic target for treating neurodegenerative diseases.
Sonic hedgehog signalling in T-cell development and activation
2007年8月10日 · SHH and activation of the SHH-signalling pathway in developing thymocytes and T-cells influence TCR repertoire selection and differentiation from DP to SP cell, and inhibit T-cell activation...
Sonic hedgehog signalling pathway: a complex network
Sonic Hedgehog (Shh) signalling cascade is one of the intricate signal transduction mechanisms that govern the precisely regulated developmental processes of multicellular organisms. Along with establishing the patterns of cellular differentiation to direct complex organ formation, it …
The Sonic Hedgehog–Patched–Gli Pathway in Human Development and Disease
The Sonic Hedgehog–Patched–Gli Pathway in Human Development and Disease - PMC. Journal List. Am J Hum Genet. v.67 (5); 2000 Nov. PMC1288546. As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health.