Serpins are a superfamily of proteins with similar structures that were first identified for their protease inhibition activity and are found in all kingdoms of life. [1][2] The acronym serpin was …

丝氨酸蛋白酶抑制剂（英語： serpin ；serine protease inhibitors）是具有相似结构蛋白质的蛋白质超家族，它是由于蛋白酶抑制活性被识别的，和在生命的各个界被发现的第一个蛋白质超家族 …

Serpin E1 蛋白是一种调节 TMPRSS7 的丝氨酸蛋白酶抑制剂，也是组织型纤溶酶原激活剂 (PLAT) 和尿激酶型纤溶酶原激活剂 (PLAU) 的主要抑制剂。 它可以显着下调纤维蛋白溶解并控制血栓 …

AAT belongs to a superfamily of serine protease inhibitors known as serpins. Advances in screening technologies have, however, resulted in many members of the serpin superfamily …

2006年7月5日 · Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many …

先前已有研究证明SerpinB9（Sb9）可以保护肿瘤细胞免受颗粒酶B（GrB）诱导的细胞凋亡，Sb9是GrB的生理抑制剂，GrB在被细胞毒性淋巴细胞递送到靶…

2003年11月1日 · Serpins are homologous proteins with diverse functions, and are involved in processes such as blood coagulation, fibrinolysis, programmed cell death, development and …

The serpins are a family of proteins with a shared tertiary structure, whose members largely act as serine protease inhibitors, found in all forms of life, ranging from viruses, bacteria, and archaea …

2024年8月19日 · 丝氨酸蛋白酶抑制剂（Serpins, serine protease inhibitors）通过抑制丝氨酸蛋白酶，调节各种生理过程，包括凝血、炎症、免疫反应和细胞迁移。 迄今为止，在人体中已鉴 …

Serine protease inhibitors, or serpins, function as central regulators for many vital processes in the mammalian body, maintaining homeostasis for clot formation and breakdown, immune …

Serpins are a class of proteins involved in the regulation of serine and other types of proteases. In humans, the majority of serpins regulate the functions of proteases involved in the body's …

2021年3月30日 · Serine proteases drive important physiological processes such as coagulation, fibrinolysis, inflammation and angiogenesis. These proteases are controlled by serine protease …

2011年7月1日 · In this short review, I introduce the serpin structure and general mechanism of protease inhibition, and illustrate, using recent crystallographic and biochemical data on …

2006年5月30日 · Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many …

In this short review, I introduce the serpin structure and general mechanism of protease inhibition, and illustrate, using recent crystallographic and biochemical data on antithrombin (AT), how …

Serine proteases drive important physiological processes such as coagulation, fibrinolysis, inflammation and angiogenesis. These proteases are controlled by serine protease inhibitors …

2025年3月10日 · Serpin, serine protease inhibitor domain; RCL, reactive centre loop. Extended Data Fig. 5 Structural prediction of the influence of Z-M398delFS somatic mutation.

Serine protease inhibitors are ubiquitous regulators for a multitude of pathways in humans. The serpins represent an ancient pathway now known to be present in all kingdoms and often …

6 天之前 · Structure of Ts-serpin and Tp-serpin. The structure of the Tp-serpin (amino acids 3-377) was resolved by molecular replacement based on data collected in space group P6 2 2 2 …

2018年4月5日 · Serpins are a broadly distributed superfamily of protease inhibitors that are present in all kingdoms of life. The acronym, serpin, is derived from their function as potent …