Serpins are a superfamily of proteins with similar structures that were first identified for their protease inhibition activity and are found in all kingdoms of life. [1][2] The acronym serpin was originally coined because the first serpins to be identified act on chymotrypsin-like serine proteases (ser ine p rotease in hibitors). [3][4][5] They...

丝氨酸蛋白酶抑制剂（英語： serpin ；serine protease inhibitors）是具有相似结构蛋白质的蛋白质超家族，它是由于蛋白酶抑制活性被识别的，和在生命的各个界被发现的第一个蛋白质超家族 [1] 。

Serpin E1 蛋白是一种调节 TMPRSS7 的丝氨酸蛋白酶抑制剂，也是组织型纤溶酶原激活剂 (PLAT) 和尿激酶型纤溶酶原激活剂 (PLAU) 的主要抑制剂。 它可以显着下调纤维蛋白溶解并控制血栓降解。

AAT belongs to a superfamily of serine protease inhibitors known as serpins. Advances in screening technologies have, however, resulted in many members of the serpin superfamily being identified as having differential expression across a multitude of chronic lung diseases compared to healthy individuals.

2006年7月5日 · Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways.

先前已有研究证明SerpinB9（Sb9）可以保护肿瘤细胞免受颗粒酶B（GrB）诱导的细胞凋亡，Sb9是GrB的生理抑制剂，GrB在被细胞毒性淋巴细胞递送到靶…

2003年11月1日 · Serpins are homologous proteins with diverse functions, and are involved in processes such as blood coagulation, fibrinolysis, programmed cell death, development and inflammation (Carrell, Pemberton, & Boswell, 1987; Gettins, …

The serpins are a family of proteins with a shared tertiary structure, whose members largely act as serine protease inhibitors, found in all forms of life, ranging from viruses, bacteria, and archaea to plants and animals. These proteins represent up to 2–10% of proteins in the human blood and are the third most common protein family.

2024年8月19日 · 丝氨酸蛋白酶抑制剂（Serpins, serine protease inhibitors）通过抑制丝氨酸蛋白酶，调节各种生理过程，包括凝血、炎症、免疫反应和细胞迁移。 迄今为止，在人体中已鉴定出37种Serpins，常见的有抗凝血酶（AT，Serpin C1）、α1-抗胰蛋白酶（A1AT，Serpin A1）、纤溶酶原激活物抑制剂-1（PAI-1，Serpin E1）、补体C1酯酶抑制剂（C1INH，SERPING1）等。 （源自参考文献：doi: 10.3389/fmed.2019.00025） Serpins具有高效广泛的功能，参与调节 …

Serine protease inhibitors, or serpins, function as central regulators for many vital processes in the mammalian body, maintaining homeostasis for clot formation and breakdown, immune responses, lung function, and hormone or central nervous system activity, among many others.

Serpins are a class of proteins involved in the regulation of serine and other types of proteases. In humans, the majority of serpins regulate the functions of proteases involved in the body's response to injury. This includes roles in coagulation, fibrinolysis, inflammation, wound healing, and tissue repair.

2021年3月30日 · Serine proteases drive important physiological processes such as coagulation, fibrinolysis, inflammation and angiogenesis. These proteases are controlled by serine protease inhibitors (SERPINs) that neutralize their activity. Currently, over 1,500 SERPINs are known in nature, but only 37 SERPINs are found in humans.

2011年7月1日 · In this short review, I introduce the serpin structure and general mechanism of protease inhibition, and illustrate, using recent crystallographic and biochemical data on antithrombin (AT), how serpin activity can be modulated by cofactors.

2006年5月30日 · Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways.

In this short review, I introduce the serpin structure and general mechanism of protease inhibition, and illustrate, using recent crystallographic and biochemical data on antithrombin (AT), how serpin activity can be modulated by cofactors.

Serine proteases drive important physiological processes such as coagulation, fibrinolysis, inflammation and angiogenesis. These proteases are controlled by serine protease inhibitors (SERPINs) that neutralize their activity. Currently, over 1,500 SERPINs are known in nature, but only 37 SERPINs are found in humans.

2025年3月10日 · Serpin, serine protease inhibitor domain; RCL, reactive centre loop. Extended Data Fig. 5 Structural prediction of the influence of Z-M398delFS somatic mutation.

Serine protease inhibitors are ubiquitous regulators for a multitude of pathways in humans. The serpins represent an ancient pathway now known to be present in all kingdoms and often regulating central pathways for clotting, immunity, and even cancer in man.

5 天之前 · Structure of Ts-serpin and Tp-serpin. The structure of the Tp-serpin (amino acids 3-377) was resolved by molecular replacement based on data collected in space group P6 2 2 2 at 2.60 Å resolution. The structure of the Ts-serpin (amino acids 2-373) was resolved by molecular replacement based on data collected in space group P2 1 2 1 2 1 at 2.34 Å resolution.

2018年4月5日 · Serpins are a broadly distributed superfamily of protease inhibitors that are present in all kingdoms of life. The acronym, serpin, is derived from their function as potent serine proteases inhibitors. Early studies of serpins focused on their functions in haemostasis since modulating serine proteas …