Your genes affect your serotonin levels - Genetic Lifehacks
2021年8月6日 · Serotonin, also known as 5-hydroxytryptamine or 5-HT, is synthesized from the amino acid tryptophan by enzymes encoded by the TPH1 and TPH2 genes. The SLC6A4 gene, also known as SERT, is responsible for serotonin transport. Serotonin receptors such as HTR1A, HTR1B, and HTR2A receive the serotonin signal.
SLC6A4 Gene - GeneCards | SC6A4 Protein | SC6A4 Antibody
2024年12月10日 · This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner.
Get to know a gene: SLC6A4 - GeneSight
2017年7月13日 · Summary: The serotonin transporter gene, SLC6A4, has demonstrated the ability to predict efficacy and adverse events with SSRI treatment, particularly for patients of Caucasian ancestry. The SLC6A4 promoter has two main variants: long and short.
Genetic contributions to brain serotonin transporter levels in …
2023年9月30日 · Our observations provide additional evidence that serotonin-related genetic variants modulate adult human brain serotonin neurotransmission. Serotonin neurotransmission mediates a...
Serotonin transporter gene polymorphism and psychiatric …
In this article, we review the status of evidence for association between the serotonin gene polymorphism and some common mental disorders like affective disorders, post-traumatic stress disorder, obsessive-compulsive disorder, suicide, autism, …
Epigenetic Mechanisms of Serotonin Signaling - PMC
Histone modifications and DNA methylation represent central dynamic and reversible processes that regulate gene expression and contribute to cellular phenotypes. These epigenetic marks have been shown to play fundamental roles in a diverse set of signaling and behavioral outcomes.
Serotonin transporter: gene, genetic disorders, and ... - PubMed
The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire serotoninergic system and its receptors via modulation of extracellular fluid serotonin concentrations. Differences in SERT expression and function produced by three SERT genes and their variants show associations …
Serotonin Transporter Gene, Depressive Symptoms and …
We explored the relationship of genetic variants of the serotonin transporter gene SLC6A4, a key regulator of the serotonergic neurotransmission, with both depressive symptoms and plasma Interleukin-6 (IL-6) levels.
Serotonin and Mental Disorders: A Concise Review on Molecular ...
Serotonin is one of the most important neurotransmitters influencing mental health.1) Most serotonin is distributed outside of the central nervous system (CNS), and influences a wide range of physiologic processes in many organs.2) However, the 2% of serotonin that is present in the CNS plays a pivotal role in the etiology of many mental ...
Serotonin transporter gene variants and behavior: a ... - PubMed
The serotonin system modulates affective, cognitive and behavioral processes. A key molecular structure of this system, the serotonin transporter (SERT) gene, has been associated with many human behaviors, both normal and pathological.
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